State-dependent effects of the D2 partial agonist aripiprazole on dopamine neuron activity in the MAM neurodevelopmental model of schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0219-1
Abstract: Aripiprazole is an antipsychotic drug characterized by partial agonist activity at D2 receptors to normalize both hyperdopaminergic and hypodopaminergic states. Traditional D2 antagonist antipsychotic drugs have been shown previously to reduce dopamine neuron activity through… read more here.
Keywords: dopamine neuron; depolarization block; activity;
Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade7209
Abstract: Upon strong and prolonged excitation, neurons can undergo a silent state called depolarization block that is often associated with disorders such as epileptic seizures. Here, we show that neurons in the peripheral olfactory system undergo… read more here.
Keywords: sensory neurons; depolarization block; olfactory sensory; depolarization ... See more keywords
Unblock the Block! Preventing Inhibitory Failure to Maintain Inhibitory Restraint
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221098808
Abstract: Disrupting Epileptiform Activity by Preventing Parvalbumin Interneuron Depolarization Block Călin A, Ilie AS, Akerman CJ. J Neurosci. 2021;41(45):9452-9465. doi:10.1523/JNEUROSCI.1002-20.2021. Epub 2021 Oct 5. Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The breakdown… read more here.
Keywords: block; depolarization block; activity; inhibitory restraint ... See more keywords