A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201806957
Abstract: Patients with advanced melanoma that is of low tumor-associated antigen (TAA) expression often respond poorly to PD-1/PD-L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA… read more here.
Keywords: dual bioresponsive; combination; depot; bioresponsive drug ... See more keywords
Octreotide SC depot in patients with acromegaly and functioning neuroendocrine tumors: a phase 2, multicenter study
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3734-1
Abstract: PurposeOctreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of… read more here.
Keywords: depot; octreotide depot; acromegaly functioning; period ... See more keywords
In situ depot formation of anti-HIV fusion-inhibitor peptide in recombinant protein polymer hydrogel.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.10.024
Abstract: Most peptide drugs have short half-lives, necessitating frequent injections that may induce skin sensitivity reactions; therefore, versatile prolonged-release delivery platforms are urgently needed. Here, we focused on an oxidatively and thermally responsive recombinant elastin-like polypeptide… read more here.
Keywords: peptide; depot; hydrogel; fusion inhibitor ... See more keywords
An injectable, electrostatically interacting drug depot for the treatment of rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.10.055
Abstract: To the best of our knowledge, no studies have yet examined the electrostatic interaction of polyelectrolytes with electrolyte drugs for the treatment of rheumatoid arthritis (RA). Here, an injectable, electrostatically interacting drug depot is described.… read more here.
Keywords: interacting drug; depot; electrostatically interacting; treatment rheumatoid ... See more keywords
An Injectable In Situ Depot-Forming Lipidic Lyotropic Liquid Crystal System for Localized Intratumoral Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00782
Abstract: To address the need for localized chemotherapy against unresectable solid tumors, an injectable in situ depot-forming lipidic lyotropic liquid crystal system (L3CS) is explored that can provide spatiotemporal control over drug delivery. Although liquid crystals… read more here.
Keywords: system; liquid; depot; drug delivery ... See more keywords
Injectable Anhydrous Poly(ethylene glycol) Polymer Liquids Form Protein Depot for Extended Controlled Release Applications Via Rapid In Situ Gelation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01060
Abstract: Water-free preparation of protein delivery systems has the potential to overcome the limitations of hydrogel depot systems such as off-target reactions, functional group hydrolysis, and limited loading capacity. However, a major roadblock in the development… read more here.
Keywords: poly ethylene; controlled release; depot; ethylene glycol ... See more keywords
Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials Science"
DOI: 10.1039/d2bm00819j
Abstract: Prolonged maintenance of therapeutically-relevant levels of broadly neutralizing antibodies (bnAbs) is necessary to enable passive immunization against infectious disease. Unfortunately, protection only lasts for as long as these bnAbs remain present at a sufficiently high… read more here.
Keywords: hydrogel; supramolecular hydrogel; depot; antibody ... See more keywords
Acute Pain Management for a Tibial Plateau Fracture Shortly After a Buprenorphine XR Depot Injection: A Case Report.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of addiction medicine"
DOI: 10.1097/adm.0000000000000965
Abstract: Acute pain management of patients on buprenorphine for opioid use disorder remains a challenge. The buprenorphine extended-release depot injection which lasts for 1 month and has a higher plasma concentration of buprenorphine compared to the sublingual… read more here.
Keywords: acute pain; buprenorphine depot; depot; pain management ... See more keywords
Intracorneal Knot or Flange Depot Fixation: a New Transscleral Technique for Intraocular Implant Fixation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cataract and refractive surgery"
DOI: 10.1097/j.jcrs.0000000000000949
Abstract: ABSTRACT We report a new surgical technique of transscleral-intracorneal (TS-IC) suture fixation of intraocular lenses with suture ends located within the transparent corneal or corneal-limbal paracentesis. This novel technique significantly reduces scleral and conjunctival trauma,… read more here.
Keywords: corneal; depot; knot flange; fixation ... See more keywords
Synchronized Optimization for Service Scheduling, Train Parking and Routing at High-Speed Rail Maintenance Depot
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Intelligent Transportation Systems"
DOI: 10.1109/tits.2020.3045852
Abstract: To meet the operational requirements and to ensure safe operations, train units of a passenger railway operator require inspection and/or cleaning at the maintenance depots after running a specified mileage or time period. Accordingly, these… read more here.
Keywords: train parking; train; maintenance; service scheduling ... See more keywords
Numerical Simulation of Insulin Depot Formation and Absorption in Subcutaneous Tissue Modeled as a Homogeneous Anisotropic Porous Media.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4049811
Abstract: In this study, a numerical model of the insulin depot formation and absorption in the subcutaneous adipose tissue is developed using the commercial Computational Fluid Dynamics (CFD) software. A better understanding of these mechanisms can… read more here.
Keywords: insulin; depot; insulin depot; tissue ... See more keywords