Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02655-9
Abstract: Chronic stress causes maladaptive changes in the brain that lead to depressive behavior. In the present study, we investigate whether chronic stress alters gut microbiota compositions that are related to stress-induced maladaptive changes in the… read more here.
Keywords: stress; gram positive; stress induced; induced depressive ... See more keywords
Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biosciences"
DOI: 10.1007/s12038-021-00246-3
Abstract: Depression is characterized by indifferent and slow thinking, leading to highly unfavorable social and economic burden. Hydroxysafflor yellow A (HSYA) is a traditional Chinese medicine and has many pharmacological properties, such as anti-oxidative and anti-inflammatory… read more here.
Keywords: depressive behavior; stress; oxidative stress; depression ... See more keywords
The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.12.028
Abstract: It is known that abamectin (ABA), which is a component belonging to the group of avermectins, has been broadly used as biopesticide. Although its effect on non-target aquatic organisms is known, knowledge about its impacts… read more here.
Keywords: spatial memory; depressive behavior; mice; chronic exposure ... See more keywords
Insomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577794
Abstract: Myeloid differentiation primary response gene 88 (MyD88) is essential for microglial activation. Despite the significant role of microglia in regulating sleep homeostasis, the contribution of MyD88 to sleep is yet to be determined. To address… read more here.
Keywords: depressive behavior; insomnia depressive; mice; myd88 mice ... See more keywords
Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.11.010
Abstract: Mitochondria are responsible for providing our cells with energy, as well as regulating oxidative stress and apoptosis, and considerable evidence demonstrates that mitochondria-related alterations are prevalent during chronic stress and depression. Here, we discuss how… read more here.
Keywords: severe life; life stress; depressive behavior; stress ... See more keywords
Bupropion and varenicline administration reversed depressive behavior induced by acetamiprid exposure in mice: the role of nAChRs in depression.
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology research"
DOI: 10.1093/toxres/tfad126
Abstract: Acetamiprid (ACE), is a popular neonicotinoid pesticide, that has a high affinity for mammalian nicotinic acetylcholine receptors (nAChRs). Therefore, ACE might induce depressive effects by perturbing the cholinergic system in mammalian. The aim of this… read more here.
Keywords: exposure; bupropion varenicline; depressive behavior; ace ... See more keywords
Moxibustion alleviates depression-like behavior in rats with Crohn’s disease by inhibiting the kynurenine pathway metabolism in the gut-brain axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1019590
Abstract: Background Moxibustion is a potential therapy for inflammatory bowel disease-related depression, but its specific mechanism of action is unclear. This study aimed to investigate the molecular mechanism by which moxibustion alleviates depressive behavior in rats… read more here.
Keywords: behavior; disease; moxibustion; behavior rats ... See more keywords
The Administration of Melatonin Improved Depressive Behavior in Both Maximal Electroshock Seizure-Prone and Non-Seizure Mice After Undergoing Levetiracetam Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Turkish Journal of Pharmaceutical Sciences"
DOI: 10.4274/tjps.galenos.2025.36156
Abstract: Objectives Comorbid psychiatric disorders, especially depression, pose challenges in epilepsy. Antiepileptic drugs, including levetiracetam, can also have psychiatric adverse effects, necessitating strategies to address mood regulation. The study aims to assess the impact of melatonin… read more here.
Keywords: mice; group; administration; seizure ... See more keywords