L-Methylfolate For Bipolar I depressive episodes: An open trial proof-of-concept registry.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2016.09.053
Abstract: BACKGROUND L-methylfolate is a compelling candidate to treat bipolar I major depressive episodes. While approved as an adjunct for unipolar major depressive disorder, no studies have been done to assess the tolerability, safety, and efficacy… read more here.
Keywords: trial; treatment; registry; proof concept ... See more keywords
Major depressive episodes and mortality in the Canadian household population.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.08.030
Abstract: OBJECTIVE To explore the association between major depressive episodes (MDE) and subsequent mortality in a representative sample of the general household population, with adjustment for other determinants of mortality. METHOD The analysis used four datasets… read more here.
Keywords: household population; mde; major depressive; mortality ... See more keywords
Gastrointestinal Symptoms During Depressive Episodes in 3256 Patients with Major Depressive Disorders: Findings from the NSSD.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2021.02.039
Abstract: BACKGROUND Little is known how often depressive episodes are accompanied by gastrointestinal symptoms in major depressive disorders (MDD). The authors sought to determine the frequency and clinical correlates of gastrointestinal symptoms during episodes of depressive… read more here.
Keywords: depressive disorders; gastrointestinal symptoms; analysis; associations gastrointestinal ... See more keywords
The role of lifetime anxiety history in the course of bipolar spectrum disorders
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DOI: 10.1016/j.psychres.2018.03.087
Abstract: Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime… read more here.
Keywords: anxiety; lifetime anxiety; anxiety history; manic hypomanic ... See more keywords
A population-based twin study of the symptomatic diagnostic criteria for major depression that occur within versus outside of major depressive episodes.
Sign Up to like & getrecommendations! Published in 2023 at "Psychological medicine"
DOI: 10.1017/s0033291723001241
Abstract: BACKGROUND Are genetic risk factors for current depressive symptoms good proxies for genetic risk factors for syndromal major depression (MD)? METHODS In over 9000 twins from the population-based Virginia Adult Twin Study of Psychiatric and… read more here.
Keywords: major depression; depressive criteria; population based; twin study ... See more keywords
Shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-022-01290-9
Abstract: Patients with depressive episodes (PDE), such as unipolar disorder (UD) and bipolar disorder (BD), are often defined as distinct diagnostic categories, but increasing converging evidence indicated shared etiologies and pathophysiological characteristics across different clinical diagnoses.… read more here.
Keywords: disorder; depressive episodes; shared disease; disease sensitive ... See more keywords
IL-4 as a potential biomarker for differentiating major depressive disorder from bipolar depression
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033439
Abstract: We aimed to investigate the differential diagnosis of depressive episodes in patients with major depressive disorder (MDD) and bipolar disorder (BD) using peripheral blood cytokine expression levels. The levels of interleukin (IL)-2, IL-6, IL-10, IL-17,… read more here.
Keywords: expression levels; group; depressive episodes; depressive disorder ... See more keywords
[11C]raclopride positron emission tomography study of dopamine‐D2/3 receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects
Sign Up to like & getrecommendations! Published in 2020 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.12980
Abstract: The aim of the study was to test: (i) if D2/D3 binding in three functional subsections of striatum is different in patients with severe major depressive episodes than in controls; and (ii) if this difference… read more here.
Keywords: severe major; patients severe; major depressive; study ... See more keywords
Loneliness and depression among rural empty-nest elderly adults in Liuyang, China: a cross-sectional study
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DOI: 10.1136/bmjopen-2017-016091
Abstract: Objective To compare loneliness, depressive symptoms and major depressive episodes between empty-nest and not-empty-nest older adults in rural areas of Liuyang city, Hunan, China. Methods A cross-sectional multi-stage random cluster survey was conducted from November… read more here.
Keywords: depressive symptoms; depression; elderly adults; major depressive ... See more keywords
A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol
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DOI: 10.1186/s12888-020-02672-3
Abstract: Background Recent evidence underscores the utility of rapid-acting antidepressant interventions, such as ketamine, in alleviating symptoms of major depressive episodes (MDE). However, to date, there have been limited head-to-head comparisons of intravenous (IV) ketamine infusions… read more here.
Keywords: crossover; maintenance; treatment; major depressive ... See more keywords
A survey-wide association study to identify youth-specific correlates of major depressive episodes
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DOI: 10.1371/journal.pone.0232373
Abstract: Background Major depressive disorder is a common disease with high mortality and morbidity worldwide. Though peak onset is during late adolescence, the prevalence of major depressive disorder remains high throughout adulthood. Leveraging an association study… read more here.
Keywords: survey; study; major depressive; association ... See more keywords