Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2470
Abstract: High mobility group box 1 (HMGB1) released by neurons and microglia was demonstrated to be an important mediator in depressive‐like behaviors induced by chronic unpredictable mild stress (CUMS), which could lead to the imbalance of… read more here.
Keywords: like behaviors; chronic unpredictable; behaviors induced; induced chronic ... See more keywords
Maternal separation increases later immobility during forced swim in guinea pig pups: evidence for sensitization of a depressive‐like state
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Psychobiology"
DOI: 10.1002/dev.21444
Abstract: Early-life stress is thought to increase later vulnerability for developing depressive illness by sensitizing underlying stress-responsive systems. Guinea pig pups separated from their mother and isolated in a novel cage for 3 hr exhibit a sensitized… read more here.
Keywords: guinea; guinea pig; pig pups; separation ... See more keywords
Sensitization of depressive-like behavior is attenuated by disruption of prostaglandin synthesis days following brief early attachment-figure isolation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22237
Abstract: Childhood psychological trauma appears to sensitize stress-related neuroinflammatory systems to increase later vulnerability for depression and other stress-related mental disorders. Isolation of guinea pig pups from the maternal attachment figure for 3 h in threatening surroundings… read more here.
Keywords: attachment figure; like behavior; isolation; sensitization ... See more keywords
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuroscience research"
DOI: 10.1002/jnr.25032
Abstract: Adolescent stress predisposes individuals to increased risk for anxiety and depression in adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via regulation of GR-responsive genes involved in brain reaction to stress. Although… read more here.
Keywords: like behavior; glucocorticoid receptor; stress; anxiety depressive ... See more keywords
FOS ameliorates DNFB-induced atopic dermatitis-like skin lesions and the comorbid anxiety and depressive-like behaviors in mice by modulating the gut microbiota, neurotransmitter releases and immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12582
Abstract: BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and eczema lesions and psychiatric comorbidities. The Gut-brain-skin axis plays a pivotal role during AD development, which could might be a novel… read more here.
Keywords: like behaviors; anxiety depressive; microbiota; comorbid anxiety ... See more keywords
Baicalin reverse depressive‐like behaviors through regulation SIRT1‐NF‐kB signaling pathway in olfactory bulbectomized rats
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6340
Abstract: Depression is a common and detrimental illness that affects up to 120 million people worldwide. read more here.
Keywords: behaviors regulation; like behaviors; baicalin reverse; depressive like ... See more keywords
Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4949-x
Abstract: Rationale and objectivesDl-3-n-Butylphthalide (NBP), a small molecule compound extracted from the seeds of Apium graveolens, possesses a large range of biological effects. Here, we attempted to explore the therapeutic effects of NBP on lipopolysaccharide (LPS)-induced… read more here.
Keywords: lps induced; apoptosis; butylphthalide improves; depressive like ... See more keywords
H3K9me2 regulation of BDNF expression in the hippocampus and medial prefrontal cortex is involved in the depressive-like phenotype induced by maternal separation in male rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05896-7
Abstract: BACKGROUND Early life stress (ELS) induces a depressive-like phenotype and increases the risk of depression. Brain-derived neurotrophic factor (BDNF) has been confirmed to be involved in the pathophysiology of depression. However, the mechanism by which… read more here.
Keywords: expression hippocampus; depressive like; expression; bdnf ... See more keywords
Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2591-y
Abstract: Depression is a common mental disorder in adolescents, with a prevalence rate of 5.6%. Current anti-depressive options for adolescents are limited: psychological intervention and conventional antidepressants have low efficacy, a delayed onset of action and… read more here.
Keywords: depression; cb1 receptor; like behaviors; depressive like ... See more keywords
The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9912-4
Abstract: Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson’s disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women.… read more here.
Keywords: administration; anhedonic depressive; like behaviors; depressive like ... See more keywords
FG-4592 Improves Depressive-Like Behaviors through HIF-1-Mediated Neurogenesis and Synapse Plasticity in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00807-3
Abstract: Depression, plus the accompanying memory impairment, is one of the leading causes of disability worldwide. Thus, there is a critical need to develop new drugs based on distinct strategies. FG-4592, an inhibitor of prolyl hydroxylase,… read more here.
Keywords: depression; neurogenesis; improves depressive; depressive like ... See more keywords