Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402219
Abstract: Major depressive disorder (MDD) is a prevalent mental disorder that significantly impacts social and psychological function, but no effective medication is currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of… read more here.
Keywords: like behaviors; delivery; depressive like; circatf7ip ... See more keywords
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202309473
Abstract: Melatonin (N‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition is altered during menopausal period. The possible role of microbiome in the treatment effect of melatonin on menopausal depression remains… read more here.
Keywords: like behaviors; operated mice; alistipes inops; depressive like ... See more keywords
Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403389
Abstract: Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that… read more here.
Keywords: lysosomal tfeb; like behaviors; tfeb trpml1; trpml1 axis ... See more keywords
Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404188
Abstract: Neuroinflammation hallmarks the pathology of depression although the etiological complexity has not yet been resolved. Previous studies demonstrate that bacterial lipopolysaccharide induces depressive‐like behaviors by activating RagA‐mTOR‐p70S6K signaling pathway. The current project aims to investigate… read more here.
Keywords: like behaviors; raga overexpression; depressive like; signaling pathway ... See more keywords
Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2470
Abstract: High mobility group box 1 (HMGB1) released by neurons and microglia was demonstrated to be an important mediator in depressive‐like behaviors induced by chronic unpredictable mild stress (CUMS), which could lead to the imbalance of… read more here.
Keywords: like behaviors; chronic unpredictable; behaviors induced; induced chronic ... See more keywords
Maternal separation increases later immobility during forced swim in guinea pig pups: evidence for sensitization of a depressive‐like state
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Psychobiology"
DOI: 10.1002/dev.21444
Abstract: Early-life stress is thought to increase later vulnerability for developing depressive illness by sensitizing underlying stress-responsive systems. Guinea pig pups separated from their mother and isolated in a novel cage for 3 hr exhibit a sensitized… read more here.
Keywords: guinea; guinea pig; pig pups; separation ... See more keywords
Sensitization of depressive-like behavior is attenuated by disruption of prostaglandin synthesis days following brief early attachment-figure isolation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22237
Abstract: Childhood psychological trauma appears to sensitize stress-related neuroinflammatory systems to increase later vulnerability for depression and other stress-related mental disorders. Isolation of guinea pig pups from the maternal attachment figure for 3 h in threatening surroundings… read more here.
Keywords: attachment figure; like behavior; isolation; sensitization ... See more keywords
Astrocytic‐HSP60 Depletion Contributed to Autophagy Defects of Astrocytes and Depressive‐Like Behaviors in Male Mice
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DOI: 10.1002/glia.70060
Abstract: Depression, a prevalent mental health disorder, is multifaceted in its etiology. Growing evidence suggests that dysregulation of heat shock protein 60 (HSP60) contributes to neurological dysfunction, but its role in astrocyte‐mediated depressive‐like behaviors and neuroinflammation… read more here.
Keywords: like behaviors; etiology; hsp60; depressive like ... See more keywords
Indomethacin Partially Alleviates Depressive‐Like Behaviors in Maternally Separated Mice: Targeting Neuroinflammatory Response in the Hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70311
Abstract: Experiencing early‐life stress (ELS) plays a fundamental role in the development of mood disorders like depression in adulthood. Neuro‐immune response in the brain is coupled with depressive‐like behaviors following maternal separation (MS) stress. Indomethacin (IND)… read more here.
Keywords: mice; like behaviors; hippocampus; depressive like ... See more keywords
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuroscience research"
DOI: 10.1002/jnr.25032
Abstract: Adolescent stress predisposes individuals to increased risk for anxiety and depression in adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via regulation of GR-responsive genes involved in brain reaction to stress. Although… read more here.
Keywords: like behavior; glucocorticoid receptor; stress; anxiety depressive ... See more keywords
FOS ameliorates DNFB-induced atopic dermatitis-like skin lesions and the comorbid anxiety and depressive-like behaviors in mice by modulating the gut microbiota, neurotransmitter releases and immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12582
Abstract: BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and eczema lesions and psychiatric comorbidities. The Gut-brain-skin axis plays a pivotal role during AD development, which could might be a novel… read more here.
Keywords: like behaviors; anxiety depressive; microbiota; comorbid anxiety ... See more keywords