A Post‐synthetic Exchange/Deprotection Approach to Append Aliphatic Amines in Defective UiO‐66
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.202500110
Abstract: Aliphatic amine‐functionalised metal‐organic frameworks (MOFs) are receiving increasing attention for their potential as adsorbents for CO2. In this work, we present a two‐step post‐synthetic approach, applied to defective ZrIV‐based MOF UiO‐66, that involves the exchange… read more here.
Keywords: post synthetic; synthetic exchange; deprotection; approach ... See more keywords
A novel use of catalytic zinc-hydroxyapatite columns for the selective deprotection of N-tert-butyloxycarbonyl (BOC) protecting group using flow chemistry
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Flow Chemistry"
DOI: 10.1007/s41981-019-00052-x
Abstract: The development of a single step flow process for the deprotection of the common protecting group tert-butyloxycarbonyl (BOC) is presented. Conventional BOC deprotection methods can require up to 24 h to fully deprotect compounds and… read more here.
Keywords: butyloxycarbonyl boc; protecting group; chemistry; deprotection ... See more keywords
Fate of protected HBT based chemodosimeters after undergoing deprotection: Restoration of ESIPT or generation of emissive phenoxide?
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2019.01.008
Abstract: Abstract The -OH group protected 2-(hydroxyphenyl) benzothiazole (HBT) based ratiometric chemodosimeters have previously been reported to undergo regeneration of excited state intramolecular proton transfer (ESIPT) process upon deprotection. In the current work it is demonstrated… read more here.
Keywords: esipt; deprotection; generation; hbt ... See more keywords
Accelerated tert-butyloxycarbonyl deprotection of amines in microdroplets produced by a pneumatic spray
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Mass Spectrometry"
DOI: 10.1016/j.ijms.2018.05.009
Abstract: Abstract Protection and deprotection of organic compounds in multistep reactions using functional groups such as tert-butoxycarbonyl (Boc), is widely performed in synthetic organic chemistry. Reaction rate acceleration studies in spray-based ionization methods (electrosonic spray, paper… read more here.
Keywords: spray; rate acceleration; deprotection; reaction ... See more keywords
A Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01410
Abstract: Carbamates, typically used for the protection of amines, including Cbz, Alloc, and methyl carbamate, can be readily deprotected by treatment with 2-mercaptoethanol in the presence of potassium phosphate tribasic in N,N-dimethylacetamide at 75 °C. This… read more here.
Keywords: mediated mercaptoethanol; nucleophilic deprotection; carbamate mediated; deprotection ... See more keywords
Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03152
Abstract: We report selective removals of N-terminal and internal Cys protecting groups using different palladium complexes to facilitate the efficient chemical protein synthesis. Utilizing the orthogonal deprotection pairs, we accomplished chemical synthesis of histone H3 containing… read more here.
Keywords: different palladium; palladium complexes; cys; deprotection ... See more keywords
Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2020 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c00979
Abstract: The chemical synthesis of polypeptides involves stepwise formation of amide bonds on an immobilized solid support. The high yields required for efficient incorporation of each individual amino acid in the growing chain are often impacted… read more here.
Keywords: flow peptide; deprotection; deep learning; peptide synthesis ... See more keywords
Deprotection-Induced Morphology Transition and Immunoactivation of Glycovesicles: A Strategy of Smart Delivery Polymersomes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b04731
Abstract: We proposed the deprotection-induced block copolymer self-assembly (DISA); that is, the deprotection of hydroxyl groups resulted in in situ self-assembly of glycopolymers. In the previous studies, block copolymers soluble in common organic solvents were employed… read more here.
Keywords: transition; deprotection; deprotection induced; lipase ... See more keywords
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57456-8
Abstract: Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening,… read more here.
Keywords: deprotection; cpc shelterin; telomere deprotection; mitotic arrest ... See more keywords
Tandem deprotection/coupling for peptide synthesis in water at room temperature
Sign Up to like & getrecommendations! Published in 2017 at "Green Chemistry"
DOI: 10.1039/c7gc01575e
Abstract: A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz deprotection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded… read more here.
Keywords: tandem deprotection; synthesis water; deprotection; peptide synthesis ... See more keywords
A covalent deprotection strategy for assembling supramolecular coordination polymers from metal-organic cages.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05349j
Abstract: A Cu4L4 metal-organic cage (MOC) composed of amine-protected ligands forms supramolecular coordination polymers (SCPs) upon covalent post-assembly deprotection. The amorphous SCPs form by virtue of aniline-copper coordination and possess a tunable porosity based on the… read more here.
Keywords: coordination; covalent deprotection; deprotection; supramolecular coordination ... See more keywords