Leveraging mathematical models for optimizing filter utility at manufacturing scale
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28376
Abstract: In the production of biopharmaceuticals depth filters followed by sterile filters are often employed to remove residual cell debris present in the feed stream. In the back drop of a global pandemic, supply chains associated… read more here.
Keywords: leveraging mathematical; depth filters; models optimizing; manufacturing scale ... See more keywords
Depth filter material process interaction in the harvest of mammalian cells.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3329
Abstract: Upstream advances have led to increased mAb titers above 5 g/L in 14-day fed-batch cultures. This is accompanied by higher cell densities and process-related impurities such as DNA and Host Cell Protein (HCP), which have caused… read more here.
Keywords: cell; filter; synthetic filter; filter material ... See more keywords