Efficacy of Dequalinium Chloride vs Metronidazole for the Treatment of Bacterial Vaginosis
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.8661
Abstract: Key Points Question Is the efficacy of dequalinium chloride comparable to that of oral metronidazole for the treatment of bacterial vaginosis? Findings In this randomized clinical trial of 147 premenopausal women with bacterial vaginosis, the… read more here.
Keywords: dequalinium; efficacy; bacterial vaginosis; metronidazole ... See more keywords
Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.11.059
Abstract: Dequalinium (DQ) has been proposed as a mitochondrial targeting ligand for nanomedicines, including liposomes, given the implication of these organelles in many diseases. This original study focuses on the interactions of DQ with phosphatidylcholine bilayers… read more here.
Keywords: study; interaction dequalinium; phosphatidylcholine bilayers; dequalinium ... See more keywords
Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21175961
Abstract: Structure-based virtual screening is a truly productive repurposing approach provided that reliable target structures are available. Recent progresses in the structural resolution of the G-Protein Coupled Receptors (GPCRs) render these targets amenable for structure-based repurposing… read more here.
Keywords: virtual screening; screening campaigns; screening; structure based ... See more keywords