Highly Efficient Deracemization of Racemic 2-Hydroxy Acids in a Three-Enzyme Co-Expression System Using a Novel Ketoacid Reductase
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2760-0
Abstract: Enantiopure 2-hydroxy acids (2-HAs) are important intermediates for the synthesis of pharmaceuticals and fine chemicals. Deracemization of racemic 2-HAs into the corresponding single enantiomers represents an economical and highly efficient approach for synthesizing chiral 2-HAs… read more here.
Keywords: deracemization; hydroxy acids; ketoacid reductase; deracemization racemic ... See more keywords
Catalytic Deracemization Reactions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c02622
Abstract: Deracemization, which converts a racemate into its single enantiomer without separation of the intermediate, has gained renewed interest in asymmetric synthesis with its inherent atomic economy and high efficiency. However, this ideal process requires selective… read more here.
Keywords: energy; deracemization reactions; catalytic deracemization; deracemization ... See more keywords
Isotopically-Directed Symmetry Breaking and Enantioenrichment in Attrition-Enhanced Deracemization.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11422
Abstract: TThe evolution of homochirality via attrition-enhanced deracemization (AED) of enantiomorphic solids is carried out using molecules that differ only in the isotopic composition of a phenyl group positioned remote from the chiral center. Enanti-oenrichment consistently… read more here.
Keywords: attrition enhanced; enhanced deracemization; deracemization; isotopically directed ... See more keywords
Water-mediated deracemization of a bisporphyrin helicate assisted by diastereoselective encapsulation of chiral guests
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09443-z
Abstract: Deracemization is a powerful method by which a racemic mixture can be transformed into an excess of one enantiomer with the aid of chiral auxiliaries, but has been applied only to small chiral molecular systems.… read more here.
Keywords: bisporphyrin; water; deracemization; encapsulation chiral ... See more keywords