Deregulation of Genes Associated with Alternate Drug Resistance Mechanisms in Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2017 at "Current Microbiology"
DOI: 10.1007/s00284-017-1393-9
Abstract: Alternate mechanisms of drug resistance involving intrinsic defense pathways play an important role in development of drug resistance. Deregulation of drug efflux, cellular metabolism, and DNA repair have been indicated to have effect on drug… read more here.
Keywords: drug resistance; significant upregulation; drug; resistance ... See more keywords
Red tape, bribery and government favouritism: evidence from Europe
Sign Up to like & getrecommendations! Published in 2017 at "Crime, Law and Social Change"
DOI: 10.1007/s10611-017-9694-2
Abstract: Red tape has long been identified as a major cause of corruption, hence deregulation was advocated as an effective anticorruption tool, an advice which many country followed. However, we lack robust systematic evidence on whether… read more here.
Keywords: government favouritism; red tape; deregulation; corruption ... See more keywords
Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.059
Abstract: Deregulation of epigenetic modification by microRNAs (miRNAs) contributes to the development of estrogen deficiency, a hallmark of the multigenic endocrine disorder polycystic ovary syndrome (PCOS), but its etiology remains unclear. Previous study has pointed to… read more here.
Keywords: ccs; pcos; expression; deregulation ... See more keywords
Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.06.020
Abstract: Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27… read more here.
Keywords: air hypoxia; lethal pediatric; ependymoma; deregulation ... See more keywords
The states that opted out: Politics, power, and exceptionalism in the quest for electricity deregulation in the United States South
Sign Up to like & getrecommendations! Published in 2021 at "Energy research and social science"
DOI: 10.1016/j.erss.2021.102147
Abstract: Abstract This article addresses why southern U.S. states opted against joining regional electricity markets at the end of the 20th century by examining the history of deregulation in North Carolina, South Carolina, Georgia, and Florida.… read more here.
Keywords: deregulation; exceptionalism; energy; opted politics ... See more keywords
A theory of deregulation in public transport
Sign Up to like & getrecommendations! Published in 2020 at "Research in Transportation Economics"
DOI: 10.1016/j.retrec.2020.100953
Abstract: Abstract This paper builds a theory of deregulation and roll-out of on-road competition in the public transport sector. Focusing on the dimensions of competition, ownership and authorisation, we identify five distinct regulatory regimes: public monopoly,… read more here.
Keywords: competition; deregulation; theory deregulation; public transport ... See more keywords
Government contracting with monopoly in infrastructure provision: Regulation or deregulation?
Sign Up to like & getrecommendations! Published in 2019 at "Transportation Research Part E: Logistics and Transportation Review"
DOI: 10.1016/j.tre.2019.01.002
Abstract: This study contributes to the body of knowledge by characterizing the optimal contracts for infrastructure provision that involve the choices of investment timing, price, quality, subsidy/tax, and franchise fee in regulation and deregulation regimes; and… read more here.
Keywords: deregulation; infrastructure provision; regulation; regulation deregulation ... See more keywords
The political economy of (de)regulation: theory and evidence from the US electricity industry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Institutional Economics"
DOI: 10.1017/s1744137419000535
Abstract: Abstract The choice of whether to regulate firms or to allow them to compete is key. If demand is sufficiently inelastic, competition entails narrower allocative inefficiencies, but also smaller expected profits, and thus weaker incentives… read more here.
Keywords: political economy; deregulation; theory evidence; economy regulation ... See more keywords
Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.216
Abstract: Cancer cells reprogram their metabolism to maintain both viability and uncontrolled proliferation. Although an interplay between the genetic, epigenetic and metabolic rewiring in cancer is beginning to emerge, it remains unclear how this metabolic plasticity… read more here.
Keywords: prostate; prostate cancer; deregulation; cancer ... See more keywords
Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells
Sign Up to like & getrecommendations! Published in 2024 at "Blood Cancer Journal"
DOI: 10.1038/s41408-024-01075-x
Abstract: Additional copies of chromosome 1 long arm (1q) are frequently found in multiple myeloma (MM) and predict high-risk disease. Available data suggest a different outcome and biology of patients with amplification (Amp1q, ≥4 copies of… read more here.
Keywords: multiple myeloma; deregulation; gain1q; copies negatively ... See more keywords
Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver.
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2020.1846356
Abstract: Objective: Vanishing white matter (VWM) is a genetic brain white matter disorder caused by mutations in eIF2B. eIF2B is central in the integrated stress response (ISR), during which its activity is inhibited by various cellular… read more here.
Keywords: vwm; low protein; isr deregulation; deregulation ... See more keywords