Dereplication‐guided isolation of novel hepatoprotective triterpenoid saponins from Celosiae Semen by high‐performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time‐of‐flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.10.001
Abstract: HighlightsA dereplication strategy using HPLC–QTOF‐MS is proposed.Two novel triterpenoid saponins are identified and purified from Celosiae Semen.Their structures are elucidated by spectroscopic and chemical analyses.Their hepatoprotectivities are evaluated. ABSTRACT Although natural products (NPs) from ethnomedical… read more here.
Keywords: triterpenoid saponins; celosiae semen; hplc qtof; dereplication ... See more keywords
Dereplication of Fungal Metabolites by NMR-Based Compound Networking Using MADByTE
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.1c00841
Abstract: Strategies for natural product dereplication are continually evolving, essentially in lock step with advances in MS and NMR techniques. MADByTE is a new platform designed to identify common structural features between samples in complex extract… read more here.
Keywords: compound; dereplication fungal; dereplication; fungal metabolites ... See more keywords
Chemoinformatic Characterization of NAPROC-13: A Database for Natural Product 13C NMR Dereplication
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.4c00530
Abstract: Natural products (NPs) are secondary metabolites of natural origin with broad applications across various human activities, particularly the discovery of bioactive compounds. Structural elucidation of new NPs entails significant cost and effort. On the other… read more here.
Keywords: database; chemical; dereplication; natural product ... See more keywords
Targeted Isolation of Neuroprotective Dicoumaroyl Neolignans and Lignans from Sageretia theezans Using in Silico Molecular Network Annotation Propagation-Based Dereplication.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.8b00292
Abstract: The integration of LC-MS/MS molecular networking and in silico MS/MS fragmentation is an emerging method for dereplication of natural products. In the present study, a targeted isolation of natural products using a new in silico-based… read more here.
Keywords: annotation propagation; network; targeted isolation; annotation ... See more keywords
LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03037
Abstract: The Rosellinia sanctae-cruciana extract was subjected to detailed liquid chromatography tandem mass spectrometry studies. A total of 38 peaks were annotated to m/z 508.26, m/z 510.28, m/z 524.26, m/z 526.28, m/z 540.26, m/z 542.27, and… read more here.
Keywords: optical isomer; new optical; isomer epoxycytochalasin; dereplication ... See more keywords
Dereplication-Guided Isolation of 3‑O‑Methylfunicone from Endophytic Fungal Co-culture and Its Inhibitory Effect on Phytophthora palmivora
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c08920
Abstract: Phytophthora palmivora is a destructive pathogen infecting more than 200 plant species, including cocoa, coconut, and papaya. Endophytic fungal co-cultures provide a promising strategy to activate silent biosynthetic pathways and generate bioactive metabolites for crop… read more here.
Keywords: dereplication; methylfunicone; culture; endophytic fungal ... See more keywords
Dereplication of microbial metabolites through database search of mass spectra
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06082-8
Abstract: Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+,… read more here.
Keywords: microbial metabolites; natural products; dereplication microbial; mass ... See more keywords
Dereplication of secondary metabolites from Sophora flavescens using an LC–MS/MS-based molecular networking strategy
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DOI: 10.1038/s41598-025-94958-3
Abstract: A dereplication strategy was developed for the screening of secondary metabolites from Sophora flavescens. The strategy consisted of 4 procedures. First, the extract of the Sophora flavescens root was subjected to LC–MS/MS analysis with both… read more here.
Keywords: sophora flavescens; secondary metabolites; dereplication; strategy ... See more keywords
Dereplication of Siparuna brasiliensis extract with in vivo anti-inflammatory activity
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2121826
Abstract: Abstract Siparuna brasiliensis is a medicinal plant widely used by indigenous communities of the Amazon rainforest to treat inflammatory diseases and related pathologies. Considering its ethnopharmacological application, it constitutes an important source of biologically active… read more here.
Keywords: dereplication; vivo; brasiliensis; anti inflammatory ... See more keywords
Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00727
Abstract: In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in the number of cancer patients, in the obesity epidemics… read more here.
Keywords: actinomycetales isolated; dereplication; isolated marine; bioactivities extract ... See more keywords
Rapid Dereplication of Trunk Bark Constituents of Croton sylvaticus and Molecular Docking of Terpenoids from Three Congolese Croton Species
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26094305
Abstract: Phytochemical investigation and bioactivity evaluation of terpenoids from the Croton species were conducted. The chemical composition of C. sylvaticus was explored using chemical phytochemical screening techniques and dereplication of 13C NMR data using MixONat software… read more here.
Keywords: molecular docking; dereplication; trunk bark; croton species ... See more keywords