Dereplication‐guided isolation of novel hepatoprotective triterpenoid saponins from Celosiae Semen by high‐performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time‐of‐flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.10.001
Abstract: HighlightsA dereplication strategy using HPLC–QTOF‐MS is proposed.Two novel triterpenoid saponins are identified and purified from Celosiae Semen.Their structures are elucidated by spectroscopic and chemical analyses.Their hepatoprotectivities are evaluated. ABSTRACT Although natural products (NPs) from ethnomedical… read more here.
Keywords: triterpenoid saponins; celosiae semen; hplc qtof; dereplication ... See more keywords
Dereplication of Fungal Metabolites by NMR-Based Compound Networking Using MADByTE
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.1c00841
Abstract: Strategies for natural product dereplication are continually evolving, essentially in lock step with advances in MS and NMR techniques. MADByTE is a new platform designed to identify common structural features between samples in complex extract… read more here.
Keywords: compound; dereplication fungal; dereplication; fungal metabolites ... See more keywords
Targeted Isolation of Neuroprotective Dicoumaroyl Neolignans and Lignans from Sageretia theezans Using in Silico Molecular Network Annotation Propagation-Based Dereplication.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.8b00292
Abstract: The integration of LC-MS/MS molecular networking and in silico MS/MS fragmentation is an emerging method for dereplication of natural products. In the present study, a targeted isolation of natural products using a new in silico-based… read more here.
Keywords: annotation propagation; network; targeted isolation; annotation ... See more keywords
LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03037
Abstract: The Rosellinia sanctae-cruciana extract was subjected to detailed liquid chromatography tandem mass spectrometry studies. A total of 38 peaks were annotated to m/z 508.26, m/z 510.28, m/z 524.26, m/z 526.28, m/z 540.26, m/z 542.27, and… read more here.
Keywords: optical isomer; new optical; isomer epoxycytochalasin; dereplication ... See more keywords
Dereplication of microbial metabolites through database search of mass spectra
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DOI: 10.1038/s41467-018-06082-8
Abstract: Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+,… read more here.
Keywords: microbial metabolites; natural products; dereplication microbial; mass ... See more keywords
Dereplication of Siparuna brasiliensis extract with in vivo anti-inflammatory activity
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2121826
Abstract: Abstract Siparuna brasiliensis is a medicinal plant widely used by indigenous communities of the Amazon rainforest to treat inflammatory diseases and related pathologies. Considering its ethnopharmacological application, it constitutes an important source of biologically active… read more here.
Keywords: dereplication; vivo; brasiliensis; anti inflammatory ... See more keywords
Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00727
Abstract: In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in the number of cancer patients, in the obesity epidemics… read more here.
Keywords: actinomycetales isolated; dereplication; isolated marine; bioactivities extract ... See more keywords
A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria
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DOI: 10.3390/md15080253
Abstract: A marine-derived Stilbella fimetaria fungal strain was screened for new bioactive compounds based on two different approaches: (i) bio-guided approach using cytotoxicity and antimicrobial bioassays; and (ii) dereplication based approach using liquid chromatography with both… read more here.
Keywords: dereplication; stilbella fimetaria; marine derived; approach ... See more keywords
Dereplication by High-Performance Liquid Chromatography (HPLC) with Quadrupole-Time-of-Flight Mass Spectroscopy (qTOF-MS) and Antiviral Activities of Phlorotannins from Ecklonia cava
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DOI: 10.3390/md17030149
Abstract: Ecklonia cava is edible seaweed that is found in Asian countries, such as Japan and Korea; and, its major components include fucoidan and phlorotannins. Phlorotannins that are isolated from E. cava are well-known to have… read more here.
Keywords: mass; ecklonia cava; dereplication; cava ... See more keywords
The Three Pillars of Natural Product Dereplication. Alkaloids from the Bulbs of Urceolina peruviana (C. Presl) J.F. Macbr. as a Preliminary Test Case
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26030637
Abstract: The role and importance of the identification of natural products are discussed in the perspective of the study of secondary metabolites. The rapid identification of already reported compounds, or structural dereplication, is recognized as a… read more here.
Keywords: dereplication; three pillars; natural product; urceolina peruviana ... See more keywords