Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study.
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DOI: 10.1021/acsmedchemlett.9b00516
Abstract: Telomerase is an enzyme deputed to the maintenance of eukaryotic chromosomes; however, its overexpression is a recognized hallmark of many cancer forms. A viable route for the inhibition of telomerase in malignant cells is the… read more here.
Keywords: human telomeric; berberine human; natural alkaloid; pyridine derivative ... See more keywords