Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Pharmacology"
DOI: 10.1111/bph.17320
Abstract: NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product… read more here.
Keywords: derivative triptolidiol; natural product; discovery natural; nlrp3 ... See more keywords