Articles with "derivatives amino" as a keyword



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Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene

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Published in 2020 at "Journal of Chemical Sciences"

DOI: 10.1007/s12039-020-01834-w

Abstract: Abstract An efficient feasible route for the one-pot synthesis of novel series of urea derivatives (2a–2j) from 2-amino-3-carbomethoxythiophene (1) via in situ isocyanate has been developed, and their corresponding anticancer activities were accomplished. The series… read more here.

Keywords: urea derivatives; molecular docking; derivatives amino; amino carbomethoxythiophene ... See more keywords
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Vortioxetine derivatives with amino acid as promoiety: synthesis, activity, stability and preliminary pharmacokinetic study.

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Published in 2021 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2021.04.011

Abstract: Vortioxetine (Vot) is an effective antidepressant with unique mechanisms exerting multi-target effects. However, severe side-effects such as nausea and vomiting are commonly experienced under conditions of long-term administration. Eight amino acid modified Vot derivatives were… read more here.

Keywords: amino acid; study; vot; derivatives amino ... See more keywords