Synthesis and biological evaluation of resveratrol derivatives with anti‐breast cancer activity
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DOI: 10.1002/ardp.202000044
Abstract: Resveratrol is a natural phytoestrogen produced by plants to protect themselves from injury, UV irradiation, and fungal attack. The main active structure is E‐resveratrol, which has many pharmacological activities. As the structure of resveratrol is… read more here.
Keywords: resveratrol; derivatives anti; breast cancer; resveratrol derivatives ... See more keywords
Synthesis of Some Hybrid 7-Hydroxy Quinolinone Derivatives As Anti Breast Cancer Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-019-03827-y
Abstract: A new series of hybrid 2-Quinolinone derivatives were synthesized and structurally proved using spectral and elemental analyses data. All the prepared compounds were tested for their in vitro cytotoxic activity against MCF-7 cell line. Compounds… read more here.
Keywords: derivatives anti; synthesis hybrid; hybrid hydroxy; quinolinone derivatives ... See more keywords
Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006 - 2021.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1954617
Abstract: INTRODUCTION The hypoxic tumour microenvironment represents a persistent obstacle in the treatment of most solid tumours. In the past years, significant efforts have been made to improve the efficacy of anti-cancer drugs. Therefore, hypoxia-activated prodrugs… read more here.
Keywords: cancer drugs; derivatives anti; hypoxia activated; 2006 2021 ... See more keywords
Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies
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DOI: 10.1080/14756366.2021.1929949
Abstract: Abstract In the present study, a series of azo derivatives (TR-1 to TR-9) have been synthesised via the diazo-coupling approach between substituted aromatic amines with phenol or naphthol derivatives. The compounds were evaluated for their… read more here.
Keywords: derivatives anti; azo derivatives; gram; gram negative ... See more keywords
3D-QSAR Studies of Isatin Derivatives with Anti-Cancer In Vitro: AdvancedCoMFA, CoMSIA and Docking Methods
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DOI: 10.4172/2150-3494.1000158
Abstract: Three-dimensional quantitative structure–activity relationship (3D-QSAR) and docking methods were performed to study 47 tubulin inhibitors, isatin derivatives with anticancer activity against human monocyte-like histiocytic lymphoma human U937 cells. The established 3D-QSAR model from Comparative Molecular… read more here.
Keywords: derivatives anti; comsia; docking methods; studies isatin ... See more keywords