Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103470
Abstract: Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain… read more here.
Keywords: developments pyrazole; overview recent; anticancer agent; derivatives anticancer ... See more keywords
Triarylpyrazole Derivatives as Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation "Pyrazole Derivatives as Anticancer Agent".
Sign Up to like & getrecommendations! Published in 2021 at "Drug research"
DOI: 10.1055/a-1498-1714
Abstract: BACKGROUND During the last recent years, several anti-cancer agents were introduced for the treatment of diverse kinds of cancer. Despite their potential in the treatment of cancer, drug resistance and adverse toxicity such as peripheral… read more here.
Keywords: pyrazole; derivatives anticancer; evaluation pyrazole; pyrazole derivatives ... See more keywords
Hybridized quinoline derivatives as anticancer agents: Design, Synthesis, biological evaluation and molecular docking.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666181112121058
Abstract: OBJECTIVE Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. METHODS Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine… read more here.
Keywords: derivatives anticancer; anticancer agents; tubulin polymerization; hybridized quinoline ... See more keywords
Natural biomolecules and derivatives as anticancer immunomodulatory agents
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1070367
Abstract: Despite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers.… read more here.
Keywords: cancer; natural biomolecules; immunomodulatory agents; derivatives anticancer ... See more keywords
Design Two Novel Tetrahydroquinoline Derivatives against Anticancer Target LSD1 with 3D-QSAR Model and Molecular Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238358
Abstract: Lysine-specific demethylase 1 (LSD1) is a histone-modifying enzyme, which is a significant target for anticancer drug research. In this work, 40 reported tetrahydroquinoline-derivative inhibitors targeting LSD1 were studied to establish the three-dimensional quantitative structure–activity relationship… read more here.
Keywords: novel tetrahydroquinoline; derivatives anticancer; design two; two novel ... See more keywords
Translational role of natural coumarins and their derivatives as anticancer agents.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0375
Abstract: Natural coumarins and their derivatives isolated from various plants or microorganisms have inherent antioxidant, antibacterial, antifungal, antiviral and anticancer properties among many biological activities. Some of these coumarins and their derivatives lead to self-programmed cancer cell death… read more here.
Keywords: natural coumarins; derivatives anticancer; anticancer agents; role natural ... See more keywords