Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4
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DOI: 10.1007/s10593-017-2062-4
Abstract: A novel series of pyridine-based derivatives was synthesized and evaluated for their inhibitory activity against dipeptidyl peptidase-4 (DPP4). 5-Aminomethyl-6-(2,4-dichlorophenyl)-4-[(1H-1,2,4-triazol-1-yl)methyl]pyridine-2-carboxylic acid was identified as a potent (IC50 0.57 nM) and selective DPP4 inhibitor (DPP8/DPP4 = 238).… read more here.
Keywords: phenylpyridine derivatives; biological evaluation; peptidase; synthesis phenylpyridine ... See more keywords
Synthesis of Chalcones Derivatives and Their Biological Activities: A Review
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DOI: 10.1021/acsomega.2c01779
Abstract: Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO–CH=CH–. Due to the presence of a reactive α,β-unsaturated carbonyl group, chalcones and their derivatives possess a wide spectrum of antiproliferative, antifungal, antibacterial,… read more here.
Keywords: synthesis; synthesis chalcones; chalcones derivatives; biological activities ... See more keywords
Synthesis of 1,2,3,4-tetrahydroacridine based triazole derivatives and their biological evaluation as dual cholinesterase, α-glucosidase inhibitors
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DOI: 10.1039/d5nj02221e
Abstract: A series of new 1,2,3-triazole-linked tacrine derivatives was synthesized via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) of C4-functionalized 9-azido-1,2,3,4-tetrahydroacridines and various phenyl acetylenes including tacrine-based terminal alkynes. All the compounds were... read more here.
Keywords: tetrahydroacridine based; derivatives biological; based triazole; synthesis tetrahydroacridine ... See more keywords
Xanthorrhizol derivatives and their biological properties as caspase-7 inhibitors
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DOI: 10.1080/14786419.2024.2302919
Abstract: Abstract Xanthorrhizol (1) is known as the major terpenoid component of the rhizome of Curcuma xanthorrhiza and having some interesting biological activities. In this report, we synthesised five derivatives of 1 containing nitrogen-functional groups. Four… read more here.
Keywords: derivatives biological; biological properties; methyl; xanthorrhizol derivatives ... See more keywords