New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21879
Abstract: Novel 2-[2-(chroman-4-ylidene)hydrazinyl]-4/5-substituted thiazole derivatives (2a-i) were synthesized and investigated for their anticancer activity. Cytotoxic activity on A549 and NIH/3T3 cell lines was determined, most of the compounds exhibited high cytotoxic profile with selectivity. Selected compounds… read more here.
Keywords: derivatives containing; new chromanone; containing thiazoles; cell ... See more keywords
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
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DOI: 10.1002/ddr.22031
Abstract: Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring (1–22) was… read more here.
Keywords: derivatives containing; acid; aldose reductase; acetic acid ... See more keywords
Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4-triazole linker.
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DOI: 10.1002/ddr.22050
Abstract: A series of thioether pleuromutilin derivatives containing 1,2,4‐triazole on the side chain of C14 were designed and synthesized. The in vitro antibacterial activities experiments of the synthesized derivatives showed that compounds 72 and 73 displayed… read more here.
Keywords: design synthesis; synthesis biological; containing triazole; pleuromutilin derivatives ... See more keywords
Design, Synthesis, and Antifungal Evaluation of Novel Benzoxazole Derivatives Containing a 1,2,3‐Triazole Moiety
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700129
Abstract: For finding novel bioactive compounds with significant antifungal activities, 17 novel benzoxazole derivatives containing a 1,2,3-triazole moiety were synthesized by the copper(II) acetylacetonate-catalyzed cyclization reaction between 2-aminophenol derivatives and 1H-1,2,3-triazole-4-carbaldehyde derivatives (4a), which were prepared… read more here.
Keywords: novel benzoxazole; containing triazole; triazole moiety; benzoxazole derivatives ... See more keywords
Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02349-x
Abstract: Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-positive bacterial strains (including multidrug-resistant clinical isolates) and… read more here.
Keywords: containing aminoguanidine; aminoguanidine moiety; ursolic acid; derivatives containing ... See more keywords
Multi-colored electrochromic devices based on mixed mono- and bi-substituted 4,4′-bipyridine derivatives containing an ester group
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Electrochemistry"
DOI: 10.1007/s10800-018-1190-6
Abstract: This paper aims to develop a multi-colored electrochromic device based on mixed mono- and bi-substituted 4,4′-bipyridine derivatives containing an ester group. A series of these derivatives were synthesized, and their electrochemical and electrochromic properties were… read more here.
Keywords: mono substituted; multi colored; bipyridine derivatives; derivatives containing ... See more keywords
Synthesis and membrane-protective activity of 2,6-diisobornylphenol derivatives with N- and O-containing fragments at position 4
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1731-x
Abstract: Two series of new amide derivatives containing 2,6-diisobornylphenol moiety were synthesized based on 3,5-diisobornyl-4-hydroxybenzoic acid and 4-butylaminomethyl-2,6-diisobornylphenol. Toxicity, membrane-protective (MP) and antioxidant (AO) activity of the obtained compounds were evaluated using red blood cells of… read more here.
Keywords: membrane protective; diisobornylphenol derivatives; derivatives containing; containing fragments ... See more keywords
Cationic β-cyclodextrin derivatives containing 2-(4-isobutylphenyl)- and 2-(3-benzoylphenyl)propionic acid residues
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DOI: 10.1007/s11172-019-2497-0
Abstract: Cationic β-cyclodextrin derivatives containing residues of pharmacologically important acids linked by spacers of different lengths were obtained by treatment of mono-6-iodo-6-deoxy- and mono-6-tosyl-β-cyclodextrin with nucleophilic agents with terminal mono- and dimethylamino groups. read more here.
Keywords: cationic cyclodextrin; cyclodextrin; derivatives containing; isobutylphenyl benzoylphenyl ... See more keywords
Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety.
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DOI: 10.1016/j.bioorg.2018.06.026
Abstract: A series of novel quinazoline derivatives containing a dithioacetal moiety were designed and synthesized, and their structures were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. Bioassay results indicated… read more here.
Keywords: containing dithioacetal; derivatives containing; quinazoline derivatives; novel quinazoline ... See more keywords
Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities.
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DOI: 10.1016/j.bioorg.2018.10.031
Abstract: A new series of quinazolinone derivatives containing triazole, thiadiazole, thiosemicarbazide functionalities was synthesized and then screened for their in vitro urease inhibition properties. Most of the compounds showed excellent activity with IC50 values ranging between… read more here.
Keywords: thiosemicarbazide functionalities; vitro urease; thiadiazole thiosemicarbazide; containing triazole ... See more keywords
Carbazole derivatives containing one or two tetra-/triphenylethenyl units as efficient hole-transporting OLED emitters
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DOI: 10.1016/j.dyepig.2019.04.045
Abstract: Abstract New efficient carbazole-based emitters containing tetra-/triphenylethene units were developed for boosting efficiency of non-doped fluorescent organic light-emitting diodes. Comparable study of the properties of derivatives containing one or two tetra-/triphenylethenyl units was performed using… read more here.
Keywords: containing one; one two; two tetra; triphenylethenyl units ... See more keywords