New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21879
Abstract: Novel 2-[2-(chroman-4-ylidene)hydrazinyl]-4/5-substituted thiazole derivatives (2a-i) were synthesized and investigated for their anticancer activity. Cytotoxic activity on A549 and NIH/3T3 cell lines was determined, most of the compounds exhibited high cytotoxic profile with selectivity. Selected compounds… read more here.
Keywords: derivatives containing; new chromanone; containing thiazoles; cell ... See more keywords
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22031
Abstract: Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring (1–22) was… read more here.
Keywords: derivatives containing; acid; aldose reductase; acetic acid ... See more keywords
Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4-triazole linker.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22050
Abstract: A series of thioether pleuromutilin derivatives containing 1,2,4‐triazole on the side chain of C14 were designed and synthesized. The in vitro antibacterial activities experiments of the synthesized derivatives showed that compounds 72 and 73 displayed… read more here.
Keywords: design synthesis; synthesis biological; containing triazole; pleuromutilin derivatives ... See more keywords
Design, Synthesis, and Antifungal Evaluation of Novel Benzoxazole Derivatives Containing a 1,2,3‐Triazole Moiety
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700129
Abstract: For finding novel bioactive compounds with significant antifungal activities, 17 novel benzoxazole derivatives containing a 1,2,3-triazole moiety were synthesized by the copper(II) acetylacetonate-catalyzed cyclization reaction between 2-aminophenol derivatives and 1H-1,2,3-triazole-4-carbaldehyde derivatives (4a), which were prepared… read more here.
Keywords: novel benzoxazole; containing triazole; triazole moiety; benzoxazole derivatives ... See more keywords
Synthesis, Antibacterial Activity Evaluation and Mechanism Exploration of Indole Derivatives Containing [1,2,4]Triazole Moiety
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70112
Abstract: Bacterial diseases have been devastating plant pathogens to crops. However, there are few efficient agents to control them. Thus, it is crucial to find novel agents to protect crops from pathogenic bacteria. Here, we designed… read more here.
Keywords: triazole moiety; derivatives containing; antibacterial activity; activity ... See more keywords
Design, synthesis, herbicidal activity evaluation, and molecular docking of novel cyclohexenone derivatives containing pyrazole group as potential HPPD inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Pest management science"
DOI: 10.1002/ps.70334
Abstract: 4‐Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD), as a key enzyme for tyrosine decomposition, is a highly regarded herbicide target. In this work, a series of cyclohexenone derivatives containing a substituted pyrazole group were designed and synthesized… read more here.
Keywords: hppd; derivatives containing; cyclohexenone derivatives; pyrazole group ... See more keywords
Design, synthesis, X-ray crystal structure, and antifungal evaluation of new acetohydrazide derivatives containing a 4-thioquinazoline moiety.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8566
Abstract: BACKGROUND To find efficient agricultural fungicides, 29 new 4-thioquinazoline-containing acetohydrazide derivatives were prepared and tested for their fungicidal properties. RESULTS All of the target compounds were characterized by 1H and 13C nuclear magnetic resonance and… read more here.
Keywords: crystal; derivatives containing; structure; acetohydrazide derivatives ... See more keywords
Design and development of pyrazol‐5‐ylbenzamide derivatives containing chiral oxazoline moiety as fungicides based on molecular docking
Sign Up to like & getrecommendations! Published in 2025 at "Pest Management Science"
DOI: 10.1002/ps.8663
Abstract: Development of novel chiral antifungal agents for effective control of plant pathogens is urgently needed. In this study, a series of pyrazol‐5‐yl‐benzamide derivatives containing chiral oxazoline moiety were rationally designed and developed based on molecular… read more here.
Keywords: molecular docking; derivatives containing; containing chiral; chiral oxazoline ... See more keywords
Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02349-x
Abstract: Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-positive bacterial strains (including multidrug-resistant clinical isolates) and… read more here.
Keywords: containing aminoguanidine; aminoguanidine moiety; ursolic acid; derivatives containing ... See more keywords
Multi-colored electrochromic devices based on mixed mono- and bi-substituted 4,4′-bipyridine derivatives containing an ester group
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Electrochemistry"
DOI: 10.1007/s10800-018-1190-6
Abstract: This paper aims to develop a multi-colored electrochromic device based on mixed mono- and bi-substituted 4,4′-bipyridine derivatives containing an ester group. A series of these derivatives were synthesized, and their electrochemical and electrochromic properties were… read more here.
Keywords: mono substituted; multi colored; bipyridine derivatives; derivatives containing ... See more keywords
Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Diversity"
DOI: 10.1007/s11030-024-10894-w
Abstract: A series of indole derivatives containing quinoline structures were designed and synthesized. The synthesized compounds were characterized by NMR and HRMS. And W14 was performed by single crystal X-ray diffraction experiments. The antiviral activity studies… read more here.
Keywords: derivatives containing; antiviral activity; activity; containing quinoline ... See more keywords