Design and Synthesis of Coumarin Derivatives as Cytotoxic Agents through PI3K/AKT Signaling Pathway Inhibition in HL60 and HepG2 Cancer Cells
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DOI: 10.3390/molecules27196709
Abstract: In this study, a series of coumarin derivatives, either alone or as hybrids with cinnamic acid, were synthesized and evaluated for their cytotoxicity against a panel of cancer cells using the MTT assay. Then, the… read more here.
Keywords: pi3k akt; coumarin derivatives; cytotoxic agents; pathway inhibition ... See more keywords
Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents
Sign Up to like & getrecommendations! Published in 2019 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.253358
Abstract: Recently the quinazoline derivatives have attracted much attention for their anticancer properties. In this study a series of new brominated quinazoline derivatives (1a-1g) were synthesized in two steps. In the first step we used N-bromosuccinimide… read more here.
Keywords: synthesis novel; novel dibromo; dibromo arylquinazolinone; cytotoxic agents ... See more keywords