1H-Benzimidazole-5-carboxamidine derivatives: design, synthesis, molecular docking, DFT and antimicrobial studies
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DOI: 10.1039/d0nj01899f
Abstract: In this study, 15 new N-(cyclohexyl)-2-substituted-1H-benzimidazole-5-carboxamidine derivatives that could be new antimicrobial agents were synthesized and their antimicrobial activities were determined using the microdilution method. Some of the derivatives showed significant efficacy against MRSA and… read more here.
Keywords: design synthesis; benzimidazole carboxamidine; carboxamidine derivatives; derivatives design ... See more keywords
Pyridine appended 2-hydrazinylthiazole derivatives: design, synthesis, in vitro and in silico antimycobacterial studies
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02163c
Abstract: An array of pyridine appended 2-hydrazinylthiazole derivatives has been synthesized to discover novel chemotherapeutic agents for Mycobacterium tuberculosis (Mtb). The drug-likeness of pyridine appended 2-hydrazinylthiazole derivatives was validated using the Lipinski and Veber rules. The… read more here.
Keywords: design synthesis; antimycobacterial studies; hydrazinylthiazole derivatives; derivatives design ... See more keywords
Sphaerococcenol A Derivatives: Design, Synthesis, and Cytotoxicity
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DOI: 10.3390/md22090408
Abstract: Sphaerococcenol A is a cytotoxic bromoditerpene biosynthesized by the red alga Sphaerococcus coronopifolius. A series of its analogues (1–6) was designed and semi-synthesized using thiol-Michael additions and enone reduction, and the structures of these analogues… read more here.
Keywords: cytotoxicity; synthesis; sphaerococcenol derivatives; a549 145 ... See more keywords
New Substituted Benzoylthiourea Derivatives: From Design to Antimicrobial Applications
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DOI: 10.3390/molecules25071478
Abstract: The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development of novel antimicrobials. In this context, a series of new benzoylthiourea derivatives substituted with one or more fluorine atoms… read more here.
Keywords: antimicrobial applications; benzoylthiourea derivatives; new substituted; substituted benzoylthiourea ... See more keywords
AgGaS2 and Derivatives: Design, Synthesis, and Optical Properties
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DOI: 10.3390/nano15020147
Abstract: Silver gallium sulfide (AgGaS2) is a ternary A(I)B(III)X(VI)2-type semiconductor featuring a direct bandgap and high chemical stability. Structurally resembling diamond, AgGaS2 has gained considerable attention as a highly promising material for nonlinear optical applications such… read more here.
Keywords: aggas2 derivatives; synthesis optical; properties aggas2; design synthesis ... See more keywords