A convenient solid phase approach to obtain lipophilic 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides
Sign Up to like & getrecommendations! Published in 2018 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1421765
Abstract: ABSTRACT This paper explores the potential of a modified phosphotriester approach to the synthesis of 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides. The modification of 5′-deprotected support-bound oligonucleotides is done in two steps: i) conversion… read more here.
Keywords: rna oligonucleotides; derivatives dna; phosphoramidate derivatives; solid phase ... See more keywords
Assessment of Structural Basis for Thiazolopyridine Derivatives as DNA Gyrase-B Inhibitors.
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DOI: 10.2174/1570163820666230222151558
Abstract: BACKGROUND Tuberculosis (TB) is one of the leading causes of death in the post-Covid-19 era. It has been observed that there is a devastating condition with a 25-30% increase in TB patients. DNA gyrase B… read more here.
Keywords: dna gyrase; thiazolopyridine derivatives; derivatives dna; qsar ... See more keywords