Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines.
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DOI: 10.1016/j.ejmech.2016.11.047
Abstract: A new series of diphenylpyrimidine derivatives (DPPYs) bearing various aniline side chains at the C-2 position of pyrimidine core were synthesized as potent BTK inhibitors. Most of these inhibitors displayed improved activity against B leukemia… read more here.
Keywords: improved activity; derivatives dppys; diphenylpyrimidine derivatives; btk inhibitors ... See more keywords