Elusive Dehydroalanine Derivatives with Enhanced Reactivity
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800758
Abstract: For the first time, a simple methodology for the chemical synthesis and use of highly reactive 4‐methylenoxazol‐5(4H)‐ones from serine is presented. These dehydroalanine derivatives, which resemble the natural 4‐methylidenimidazole‐5‐one (MIO) cofactor present in lyases and… read more here.
Keywords: methodology; elusive dehydroalanine; dehydroalanine derivatives; derivatives enhanced ... See more keywords
Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00888
Abstract: Harringtonine (HT), produced from Cephalotaxus species, is known to exhibit potent antiproliferative activity against myeloid leukemia cells by inhibiting protein synthesis. A previous study using acute promyelocytic leukemia (HL-60) cells raised the possibility that the… read more here.
Keywords: harringtonine ester; ester derivatives; hela cells; antiproliferative activity ... See more keywords
New Eugenol Derivatives with Enhanced Insecticidal Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239257
Abstract: Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with… read more here.
Keywords: new eugenol; eugenol; eugenol derivatives; enhanced insecticidal ... See more keywords