Synthesis of N‐Substituted Iminosugar Derivatives and Evaluation of Their Immunosuppressive Activities
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DOI: 10.1002/cmdc.201700706
Abstract: It is important to find more effective and safer immunosuppressants, because clinically used immunosuppressive agents have significant side effects. A series of N‐substituted iminosugar derivatives were designed and synthesized, and their immunosuppressive effects were evaluated… read more here.
Keywords: inhibitory effects; derivatives evaluation; substituted iminosugar; synthesis substituted ... See more keywords
Synthesis and characterization of furazan derivatives and their evaluation as antitumor agents
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DOI: 10.1007/s11696-019-00834-6
Abstract: In order to discover compounds with better biological activity, a series of furazan derivatives were synthesized based on the structural modification of INCB024360 (Epacadostat). The anti-proliferative activities of new synthesized compounds 4a–o were screened in… read more here.
Keywords: furazan derivatives; derivatives evaluation; characterization furazan; evaluation antitumor ... See more keywords
Synthesis and Characterization of Tetrachloro-1,3-Oxazepine Derivatives and Evaluation of their Biological Activities.
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DOI: 10.17344/acsi.2019.5264
Abstract: 6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b-10b have been synthesized by reacting Schiff bases 1a-10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 ∆ 7) cycloaddition reaction conditons. All reactions had been monitored using TLC. FT IR and melting… read more here.
Keywords: oxazepine; synthesis characterization; derivatives evaluation; characterization tetrachloro ... See more keywords
Synthesis of New 2,3-Dihydroindole Derivatives and Evaluation of Their Melatonin Receptor Binding Affinity
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DOI: 10.3390/molecules27217462
Abstract: 2,3-Dihydroindoles are promising agents for the synthesis of new compounds with neuroprotective and antioxidant properties. Usually, these compounds are obtained by direct reduction of the corresponding indoles containing acceptor groups in the indole ring for… read more here.
Keywords: derivatives evaluation; new dihydroindole; dihydroindole derivatives; evaluation melatonin ... See more keywords
Synthesis of 2-Aminopyrimidine Derivatives and Their Evaluation as β-Glucuronidase Inhibitors: In Vitro and In Silico Studies
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DOI: 10.3390/molecules27227786
Abstract: Currently the discovery and development of potent β-glucuronidase inhibitors is an active area of research due to the observation that increased activity of this enzyme is associated with many pathological conditions, such as colon cancer,… read more here.
Keywords: aminopyrimidine derivatives; derivatives evaluation; glucuronidase inhibitors; evaluation glucuronidase ... See more keywords