Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.
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DOI: 10.1016/j.ejmech.2020.112112
Abstract: A new series of pyrimidine derivatives as human carbonic anhydrases (CA, EC 4.2.1.1) inhibitors is here designed by including a 5-fluorouracil (5-FU) moiety, broadly used anticancer medication, in nitrogenous base modulators of the tumor-associated CAs.… read more here.
Keywords: human carbonic; derivatives human; xii; fluorouracil moiety ... See more keywords
Current Status on 1,4-Dihydropyridine Derivatives against Human Pathogenic Parasites.
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DOI: 10.2174/0929867330666221104162901
Abstract: Infections provoked by parasites are among the most prevalent diseases worldwide and generate important health and socioeconomic problems. Despite the enormous amount of work done, the chemotherapy for most of them remains unsolved. Usually, treatments… read more here.
Keywords: dihydropyridine derivatives; derivatives human; pathogenic parasites; human pathogenic ... See more keywords
The Applications of Origanum Vulgare and Its Derivatives in Human, Ruminant and Fish Nutrition – A Review
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DOI: 10.2478/aoas-2020-0004
Abstract: Abstract Origanum vulgare L. is an aromatic enduring herb that belongs to Lamiaceae family. The bioactive constituents of this herb, such as carvacrol and thymol possess several medicinal properties, such as antioxidant, antidiabetic, anti-inflammatory, antimicrobial,… read more here.
Keywords: vulgare derivatives; ruminant fish; derivatives human; applications origanum ... See more keywords
Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3
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DOI: 10.3390/biom12101507
Abstract: Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine derivatives… read more here.
Keywords: membrane transport; derivatives human; stereoselectivity; transport ... See more keywords