Articles with "derivatives hydroxypyridinones" as a keyword



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Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors

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Published in 2022 at "ACS Medicinal Chemistry Letters"

DOI: 10.1021/acsmedchemlett.2c00434

Abstract: Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, which is a critical component of the viral replication machinery. To inhibit the activity of this metalloenzyme, small-molecule inhibitors… read more here.

Keywords: carboxylic acid; derivatives hydroxypyridinones; core scaffolds; hydroxypyridinones core ... See more keywords