Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000377
Abstract: Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one‐pot, four‐component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by 1H nuclear magnetic… read more here.
Keywords: novel hydrazone; hydrazone derivatives; incorporating pyridine; log ic50 ... See more keywords
Design, synthesis, and bioevaluation of novel oxoindolin-2-one derivatives incorporating 1-benzyl-1H-1,2,3-triazole
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02488-1
Abstract: In our search for novel bioactive molecules, three series of indolin-2-one derivatives incorporating 1-benzyl-1H-1,2,3-triazole moiety were synthesized. The compounds were initially designed as acetylcholine esterase (AChE) inhibitors based on the structural feature of donepezil, a… read more here.
Keywords: benzyl triazole; ache; incorporating benzyl; one derivatives ... See more keywords
Inactivating Activities and Mechanism of Imidazo[1,2-c]pyrimidin-5(6H)-one Nucleoside Derivatives Incorporating a Sulfonamide Scaffold.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08129
Abstract: Twenty-eight imidazo[1,2-c]pyrimidin-5(6H)-one nucleoside derivatives incorporating a sulfonamide scaffold with preferable inactivating activities on pepper mild mottle virus (PMMoV) were designed and synthesized. Then, compound B29 with illustrious inactivating activity against PMMoV was received on the… read more here.
Keywords: nucleoside derivatives; derivatives incorporating; pmmov; imidazo pyrimidin ... See more keywords
Facile Synthesis of Novel Vanillin Derivatives Incorporating a Bis(2-hydroxyethyl)dithhioacetal Moiety as Antiviral Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01035
Abstract: A series of vanillin derivatives incorporating a bis(2-hydroxyethyl)dithioacetal moiety was designed and synthesized via a facile method. A plausible reaction pathway was proposed and verified by computational studies. Bioassay results demonstrated that target compounds possessed… read more here.
Keywords: bis hydroxyethyl; derivatives incorporating; vanillin derivatives; incorporating bis ... See more keywords
Synthesis of thiazolidinone and methylthiazole derivatives incorporating benzodioxole moiety and evaluation of their antimicrobial activity
Sign Up to like & getrecommendations! Published in 2024 at "Synthetic Communications"
DOI: 10.1080/00397911.2024.2387118
Abstract: Abstract One of the most serious future challenges to health care professionals is the emergence of multi-drug resistance pathogenic microbes that rapidly develop resistance to currently used antibiotics. So, as a way to overcome the… read more here.
Keywords: methylthiazole derivatives; thiazolidinone methylthiazole; incorporating benzodioxole; antimicrobial activity ... See more keywords
The Discovery of Novel Ferulic Acid Derivatives Incorporating Substituted Isopropanolamine Moieties as Potential Tobacco Mosaic Virus Helicase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213991
Abstract: Target-based drug design, a high-efficiency strategy used to guide the development of novel pesticide candidates, has attracted widespread attention. Herein, various natural-derived ferulic acid derivatives incorporating substituted isopropanolamine moieties were designed to target the tobacco… read more here.
Keywords: tmv helicase; incorporating substituted; derivatives incorporating; helicase ... See more keywords