Azole derivatives inhibit wildtype butyrylcholinesterase and its common mutants.
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DOI: 10.1002/ddr.22071
Abstract: Azoles, which have been used for antifungal chemotherapy for decades, have recently been of interest for their efficacy against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). There is little known about the potential of azoles against BChE,… read more here.
Keywords: azole derivatives; derivatives inhibit; bche; inhibit wildtype ... See more keywords
Thiourea derivatives inhibit key diabetes‐associated enzymes and advanced glycation end‐product formation as a treatment for diabetes mellitus
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DOI: 10.1002/iub.2699
Abstract: This study was designed to screen novel thiourea derivatives against different enzymes, such as α‐amylase, α‐glucosidase, protein tyrosine phosphatase 1 B, and advanced glycated end product (AGEs). A cytotoxicity analysis was performed using rat L6… read more here.
Keywords: thiourea derivatives; end product; thiourea; derivatives inhibit ... See more keywords
ROS-Scavenging Selenofluoxetine Derivatives Inhibit In Vivo Serotonin Reuptake
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DOI: 10.1021/acsomega.1c05567
Abstract: While the neurochemistry that underpins the behavioral phenotypes of depression is the subject of many studies, oxidative stress caused by the inflammation comorbid with depression has not adequately been addressed. In this study, we described… read more here.
Keywords: selenofluoxetine derivatives; ros scavenging; derivatives inhibit; inhibit vivo ... See more keywords
Coumarin derivatives inhibit the aggregation of β-lactoglobulin
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DOI: 10.1039/d2ra01029a
Abstract: The binding of a small molecule to a protein through non-covalent interactions mainly depends on its size and electronic environment. Such binding can change the stability of the three dimensional protein structure which sometimes may… read more here.
Keywords: inhibit aggregation; aggregation; derivatives inhibit; lactoglobulin ... See more keywords
Novel betulin derivatives inhibit IFN-γ and modulates COX-2 expression
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DOI: 10.1080/14786419.2018.1528581
Abstract: Abstract Betulin (BE) is a pentacyclic triterpenes, obtained from natural sources and with several biological activities described, such as anti-tumoral and anti-inflammatory activities. The BE esterification at hydroxyl group (C-3 and C-28) resulted in five… read more here.
Keywords: derivatives inhibit; cox expression; betulin derivatives; expression ... See more keywords
Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation
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DOI: 10.3390/molecules27134054
Abstract: Coumarin was first discovered in Tonka bean and then widely in other plants. Coumarin has an anticoagulant effect, and its derivative, warfarin, is a vitamin K analogue that inhibits the synthesis of clotting factors and… read more here.
Keywords: aggregation; derivatives inhibit; six coumarin; coumarin derivatives ... See more keywords