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Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s137608
Abstract: Objective To discover novel isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins (IAP) for the treatment of ovarian cancer. Methods We first synthesized 533 isoquinoline derivatives, and screened them using CCK-8 to measure their…
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Keywords:
apoptosis;
derivatives inhibition;
treatment;
ovarian cancer ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416011
Abstract: The effective antiviral agents that treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed around the world. The 3C-like protease (3CLpro) of SARS-CoV-2 plays a pivotal role in virus replication; it also has…
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Keywords:
derivatives inhibition;
cov 3clpro;
identification darunavir;
inhibition sars ... See more keywords