New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21061923
Abstract: In this paper, a novel series of imidazole-based heme oxygenase-1 (HO-1) inhibitors is reported. These compounds were obtained by modifications of previously described high potent and selective arylethanolimidazoles. In particular, simplification of the central linker… read more here.
Keywords: arylethanolimidazole derivatives; breast; derivatives inhibitors; breast cancer ... See more keywords
Synthesis of thienopyrimidine derivatives as inhibitors of STAT3 activation induced by IL-6.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1811.11046
Abstract: A series of thienopyrimidine compounds (6Aa-g and 6Ba-d) were synthesized and characterized by NMR spectroscopy and mass spectrometry. These compounds (6Aa-g and 6Ba-d) potently inhibited STAT3 expression induced by IL-6 in a dose-dependent manner with… read more here.
Keywords: thienopyrimidine; synthesis thienopyrimidine; derivatives inhibitors; inhibitors stat3 ... See more keywords