Design, synthesis, and biological evaluation of new 1,4‐diarylazetidin‐2‐one derivatives (β‐lactams) as selective cyclooxygenase‐2 inhibitors
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DOI: 10.1002/ardp.201900293
Abstract: A new series of 1,4‐diarylazetidin‐2‐one derivatives (β‐lactams) were designed and synthesized to evaluate their biological activities as selective cyclooxygenase‐2 (COX‐2) inhibitors. In vitro COX‐1 and COX‐2 inhibition studies showed that all compounds were selective inhibitors… read more here.
Keywords: one derivatives; new diarylazetidin; selective cyclooxygenase; derivatives lactams ... See more keywords
N-Alkylation of N-trimethylsilyl derivatives of lactams, amides, and imides with alkyl sulfonates
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DOI: 10.1007/s11172-020-2775-x
Abstract: The reaction of N -trimethylsilyl derivatives of amides and imides with alkyl sulfonates on heating affords the corresponding N -alkyl derivatives and trimethylsilyl sulfonates. read more here.
Keywords: alkylation trimethylsilyl; amides imides; trimethylsilyl derivatives; derivatives lactams ... See more keywords