Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics
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DOI: 10.1016/j.steroids.2017.09.013
Abstract: Graphical abstract Figure. No Caption available. HighlightsFirst reported 17&bgr;‐amide derivatives of 2‐methoxyestradiol.The single crystal X‐ray diffraction confirmed the configuration of 17&bgr;‐butyrylamino of 6c.Three derivatives had similar or even better effects than 2‐ME in antiproliferative assay.Pharmacokinetic… read more here.
Keywords: amide derivatives; bgr; derivatives methoxyestradiol; antiproliferative effect ... See more keywords