Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2170370
Abstract: Abstract A series of 4-methyl-1,2,3-benzoxathiazine-2,2-dioxides with various substituents in 5, 6 or 7 positions was obtained from corresponding 2’-hydroxyacetophenones in their reaction with sulphamoyl chloride. 6- and 7-aryl substituted 4-methyl-1,2,3-benzoxathiazine-2,2-dioxides were obtained from aryl substituted… read more here.
Keywords: human carbonic; benzoxathiazine dioxides; methyl benzoxathiazine; benzoxathiazine ... See more keywords
Crystallographic studies of piperazine derivatives of 3-methyl-5-spirofluorenehydantoin in search of structural features of P-gp inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229621006756
Abstract: 5-Spirofluorenehydantoin derivatives show efflux modulating, cytotoxic and antiproliferative effects in sensitive and resistant mouse T-lymphoma cells. In order to extend the knowledge available about the pharmacophoric features responsible for the glycoprotein P (P-gp) inhibitory properties… read more here.
Keywords: crystallographic studies; derivatives methyl; spirofluorenehydantoin search; methyl spirofluorenehydantoin ... See more keywords