Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
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DOI: 10.1021/acsomega.0c01879
Abstract: Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through the inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family, potentially limiting its usability. The… read more here.
Keywords: alkoxythieno isoquinolin; derivatives parp; isoquinolin ones; isoquinolin ... See more keywords