Synthesis of Cholestan -3-One Derivatives Possessing a C-2 Spiro-Oxindole Substituent
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Research"
DOI: 10.3184/174751918x15161933697781
Abstract: A series of C-2 cholestan-3-one spiro-oxindole derivatives were prepared by the 1:3 dipolar cycloaddition reaction between the cholestan-3-one substituted by a C-2 arylidene and the azomethine ylid derived from isatin and sarcosine. The dipolarophiles were… read more here.
Keywords: cholestan one; one derivatives; possessing spiro; derivatives possessing ... See more keywords
Synthesis, antifungal activity and potential mechanism of fusidic acid derivatives possessing amino-terminal groups.
Sign Up to like & getrecommendations! Published in 2020 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0289
Abstract: Aim: Fusidic acid (FA) is a narrow-spectrum bacteriostatic antibiotic. We inadvertently discovered that a FA derivative modified by an amino-terminal group at the 3-OH position, namely 2, inhibited the growth of Cryptococcus neoformans. Methods &… read more here.
Keywords: amino terminal; derivatives possessing; antifungal activity; fusidic acid ... See more keywords