Synthesis of arylfuran derivatives as potential antibacterial agents
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02711-y
Abstract: Bacterial infections represent a serious health care problem mainly due to the misuse and overuse of antibiotics, with consequent emergence of multidrug resistant bacterial strains. Then, because the urgent need to find novel and alternative… read more here.
Keywords: arylfuran derivatives; synthesis arylfuran; derivatives potential; antibacterial agents ... See more keywords
In silico study of carvone derivatives as potential neuraminidase inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-018-3619-6
Abstract: Recent outbreaks of highly pathogenic influenza strains have highlighted the need to develop new anti-influenza drugs. Here, we report an in silico study of carvone derivatives to analyze their binding modes with neuraminidase (NA) active… read more here.
Keywords: silico study; derivatives potential; study carvone; carvone derivatives ... See more keywords
99mTc-radiolabeled imidazo[2,1-b]benzothiazole derivatives as potential radiotracers for glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-019-06945-4
Abstract: This study presents [99mTc]BPTG-1 and [99mTc]BPTG-2 for glioblastoma imaging. In vitro cellular uptakes of these radiotracers were examined in SKOV-3, MCF-7, U87-MG, HT-29, and A549 cell lines. U87-MG cell line displayed the highest radiotracers uptakes.… read more here.
Keywords: 99mtc radiolabeled; radiolabeled imidazo; benzothiazole derivatives; potential radiotracers ... See more keywords
5-(Halomethyl)uridine derivatives as potential antitumor radiosensitizers: A DFT study
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2017.12.062
Abstract: Abstract Considering the fact that the efficiency of the uridine-5-methyl radical in producing cytotoxic DNA intrastrand cross-link lesions is greatly higher than that of the uridine-5-yl radical, the radiosensitizing action of 5-(halomethyl)uridines (5-XCH2U, X = F, Cl,… read more here.
Keywords: derivatives potential; antitumor radiosensitizers; uridine derivatives; halomethyl uridine ... See more keywords
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.020
Abstract: A small library of coumarins, carrying butynyl-amino chains, was synthesized continuing our studies in the field of MDR reverting ageEnts and in order to obtain multipotent agents to combat malignancies. In particular, the reported anticancer… read more here.
Keywords: derivatives potential; coumarin; coumarin derivatives; antitumor ... See more keywords
Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.035
Abstract: Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two… read more here.
Keywords: anti inflammatory; pyridazinone derivatives; derivatives potential; biological evaluation ... See more keywords
Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.012
Abstract: In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic… read more here.
Keywords: design synthesis; synthesis docking; docking studies; studies benzimidazole ... See more keywords
Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113108
Abstract: In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC50 = 0.96 μM), being around 38-fold selectivity over GES-1.… read more here.
Keywords: mgc 803; discovery triazolo; triazolo pyrimidines; derivatives potential ... See more keywords
One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01301
Abstract: Cancer is a leading cause of death worldwide. Recent research studies have revealed that GM3 derivatives have considerable promise as potential therapeutic agents for cancer. To discover novel GM3 derivatives as potential antitumor agents, a… read more here.
Keywords: cancer; gm3 derivatives; derivatives potential; one pot ... See more keywords
Investigating the novel acetonitrile derivatives as potential SARS-CoV-2 main protease inhibitor using molecular modeling approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2059568
Abstract: Abstract The COVID-19 is declared a pandemic by World Health Organization (WHO). It causes respiratory illness which leads to oxygen deficiency; it has affected millions of lives all around the globe. It has also been… read more here.
Keywords: binding affinity; protease; acetonitrile derivatives; main protease ... See more keywords
Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1518958
Abstract: Abstract A variety of substituted 3-arylcoumarin derivatives were synthesised through microwave radiation heating. The method has characteristics of environmental friendliness, economy, simple separation, and purification process, less by-products and high reaction yield. Those 3-arylcoumarin derivatives… read more here.
Keywords: arylcoumarin derivatives; derivatives potential; biological evaluation; evaluation arylcoumarin ... See more keywords