Novel derivatives of substituted 6-fluorobenzothiazole diamides: synthesis, antifungal activity and cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1894-x
Abstract: A new series of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl diamides were synthesized in vitro as potential antifungal agents. Chemical structures of the synthesised compounds were substantiated by IR, 1H, 13C, 19F nuclear magnetic resonance spectra, high resolution mass… read more here.
Keywords: diamides synthesis; derivatives substituted; fluorobenzothiazole diamides; cytotoxicity ... See more keywords
Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.054
Abstract: The alarming growth of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) has become a major global health hazard. Therefore, urgent demand for new antibiotics with a unique mechanism of action… read more here.
Keywords: derivatives substituted; synthesis antibacterial; pleuromutilin derivatives; antibacterial activities ... See more keywords
New Derivatives of 5-Substituted Uracils: Potential Agents with a Wide Spectrum of Biological Activity
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DOI: 10.3390/molecules27092866
Abstract: Pyrimidine nucleoside analogues are widely used to treat infections caused by the human immunodeficiency virus (HIV) and DNA viruses from the herpes family. It has been shown that 5-substituted uracil derivatives can inhibit HIV-1, herpes… read more here.
Keywords: herpes family; nucleoside analogues; derivatives substituted; biological activity ... See more keywords