Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
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DOI: 10.1016/j.ejmech.2018.01.058
Abstract: A series of twenty-six carbamates derived from aminocombretastatin A-4 (AmCA-4) were synthesized and evaluated for their capacity to affect cell proliferation, tubulin polymerization, mitotic cell arrest, microtubule network organization, apoptosis and endothelial tubular structures in vitro.… read more here.
Keywords: derived aminocombretastatin; disrupting agents; vascular disrupting; carbamates derived ... See more keywords