Longitudinal micro-computed tomography-derived biomarkers quantify non-resolving lung fibrosis in a silicosis mouse model
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73056-6
Abstract: In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis remains a life-threatening condition for which highly effective treatment is still lacking. Towards improving the success-rate of bench-to-bedside translation, we investigated in… read more here.
Keywords: non resolving; fibrosis; lung fibrosis; resolving lung ... See more keywords
Plasma extracellular nanovesicle (exosome)‐derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13793
Abstract: Demonstrate the presence of cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) proteins and mRNAs in isolated human plasma exosomes and evaluate the capacity for exosome‐derived biomarkers to characterize variability in CYP3A4 activity. read more here.
Keywords: characterize variability; plasma extracellular; drug; derived biomarkers ... See more keywords
Early Adverse Event Derived Biomarkers in Predicting Clinical Outcomes in Patients with Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092521
Abstract: Simple Summary This paper presents a paradigm-shifted approach for adverse event (AE) analysis from classic descriptive summary into modern informative statistics to fulfill precision medicine. It defines early AE and derives a series of innovative… read more here.
Keywords: derived biomarkers; clinical outcomes; grade; event ... See more keywords