Predicting the impact of CPAP on brain health: A study using the sleep EEG‐derived brain age index
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.52032
Abstract: This longitudinal study investigated potential positive impact of CPAP treatment on brain health in individuals with obstructive sleep Apnea (OSA). To allow this, we aimed to employ sleep electroencephalogram (EEG)‐derived brain age index (BAI) to… read more here.
Keywords: brain; impact cpap; brain health; eeg derived ... See more keywords
Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-025-04043-x
Abstract: Unraveling the associations between human exposure to environmental chemicals and potential neurotoxicity presents significant challenges. Evaluation of neurotoxicity potential using animal testing is resource-intensive (financial, labor, and animal use) and faces uncertainties regarding biological relevance… read more here.
Keywords: neurotoxicity; microelectrode array; mea assay; ipsc derived ... See more keywords
BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids
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DOI: 10.1038/s41420-022-00845-5
Abstract: β-site APP-cleaving enzyme 2 (BACE2) is a homolog of BACE1, which is considered as the most promising therapeutic target for Alzheimer’s disease (AD). However, the expression and functional role of BACE2 in central nervous system… read more here.
Keywords: hscr; bace2; derived brain; brain organoids ... See more keywords
Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.830432
Abstract: The centrosome is composed of a pair of centrioles and serves as the major microtubule-organizing center (MTOC) in cells. Centrosome dysfunction has been linked to autosomal recessive primary microcephaly (MCPH), which is a rare human… read more here.
Keywords: hipsc derived; derived brain; brain organoids; cpap e1235v ... See more keywords