Identification of alternative splicing-derived cancer neoantigens for mRNA vaccine development
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab553
Abstract: Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to the advantages in safety, efficacy and industrial production. However, it remains a challenge to identify suitable cancer neoantigens that can be targeted… read more here.
Keywords: derived cancer; alternative splicing; cancer neoantigens; splicing derived ... See more keywords
Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201642360
Abstract: Although proteasome inhibitors (PIs) are used as anticancer drugs to treat various cancers, their relative therapeutic efficacy on stem cells vs. bulk cancers remains unknown. Here, we show that stem cells derived from gliomas, GSCs,… read more here.
Keywords: cancer stem; apoptosis; glioma derived; derived cancer ... See more keywords
Patient-derived cancer models: Valuable platforms for anticancer drug testing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.976065
Abstract: Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority metastatic disease is incurable due to the onset of drug resistance. Preclinical models including genetically… read more here.
Keywords: oncology; patient derived; drug; derived cancer ... See more keywords
Transportan 10 Induces Perturbation and Pores Formation in Giant Plasma Membrane Vesicles Derived from Cancer Liver Cells
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030492
Abstract: Continuous progress has been made in the development of new molecules for therapeutic purposes. This is driven by the need to address several challenges such as molecular instability and biocompatibility, difficulties in crossing the plasma… read more here.
Keywords: microscopy; giant plasma; membrane; derived cancer ... See more keywords
The Patient-Derived Cancer Organoids: Promises and Challenges as Platforms for Cancer Discovery
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DOI: 10.3390/cancers14092144
Abstract: Simple Summary The biopharmaceutical industry increasingly focuses on the development of new anticancer drugs for effective cancer therapy. Despite these efforts, the success rate is low, and thereby, greater efficacy and better safety properties are… read more here.
Keywords: derived cancer; biology; patient derived; model ... See more keywords
Application of Patient-Derived Cancer Organoids to Personalized Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050789
Abstract: Cell models are indispensable for the research and development of cancer therapies. Cancer medications have evolved with the establishment of various cell models. Patient-derived cell lines are very useful for identifying characteristic phenotypes and susceptibilities… read more here.
Keywords: derived cancer; biology; patient derived; personalized medicine ... See more keywords