Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced functional materials"
DOI: 10.1002/adfm.201704939
Abstract: The last decade has seen impressive progress in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) that makes them ideal tools to repair injured hearts. To achieve an optimal outcome, advanced molecular imaging methods are essential to… read more here.
Keywords: cell derived; photoacoustic imaging; stem cell; derived cardiomyocytes ... See more keywords
A method to measure data complexity of a complicated medical data set
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Imaging Systems and Technology"
DOI: 10.1002/ima.22760
Abstract: In this article, we consider data complexity in the context of calcium transient signal data collected from induced pluripotent stem cell‐derived cardiomyocytes. We present a novel way to measure data complexity based on the nearest… read more here.
Keywords: data complexity; calcium; derived cardiomyocytes; measure data ... See more keywords
Mining Exosomal MicroRNAs from Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes for Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_10
Abstract: Myocardial infarction is the leading cause of morbidity and mortality worldwide. Recent advances in cardiac regenerative therapy have allowed for novel modalities in replenishing the damaged myocardium. However, poor long-term engraftment and survival of transplanted… read more here.
Keywords: cell; cells derived; derived cardiomyocytes; pluripotent stem ... See more keywords
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.040
Abstract: Pluripotent stem cells (PSCs) offer unprecedented opportunities for disease modeling and personalized medicine. However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish. This has emerged as a major obstacle for their application for late-onset… read more here.
Keywords: psc cms; cms; neonatal transplantation; psc derived ... See more keywords
Assessment of Cardiotoxicity With Stem Cell-Based Strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2020.08.012
Abstract: PURPOSE Adverse cardiovascular drug effects pose a substantial medical risk and represent a common cause of drug withdrawal from the market. Thus, current in vitro assays and in vivo animal models still have shortcomings in assessing cardiotoxicity.… read more here.
Keywords: stem cell; cardiotoxicity; derived cardiomyocytes; cell derived ... See more keywords
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.05.004
Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our physiological… read more here.
Keywords: hipsc derived; hipsc; derived cardiomyocytes; pluripotent stem ... See more keywords
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.12.016
Abstract: Summary Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease pathology and provides distinct readouts in… read more here.
Keywords: cell derived; derived cardiomyocytes; contractility; pathology ... See more keywords
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell reports"
DOI: 10.1016/j.stemcr.2022.01.009
Abstract: Human induced pluripotent stem cell-derived cardiomyocytes have been established to detect dynamic calcium transients by fast kinetic fluorescence assays that provide insights into specific aspects of clinical cardiac activity. However, the precise derivation and use… read more here.
Keywords: waveform parameters; predict cardiac; cardiac activity; derived cardiomyocytes ... See more keywords
Inotropic Assessment in Engineered 3D Cardiac Tissues using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in the BiowireTM II Platform.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2020.106886
Abstract: To develop therapeutics for cardiovascular disease, especially heart failure, translational models for assessing cardiac contractility are necessary for preclinical target validation and lead optimization. The availability of stem cell-derived cardiomyocytes (SC-CM) has generated a great… read more here.
Keywords: cell derived; stem cell; derived cardiomyocytes; biowiretm platform ... See more keywords
Manipulation-free cultures of human iPSC-derived cardiomyocytes offer a novel screening method for cardiotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.183
Abstract: Induced pluripotent stem cell (iPSC)-based cardiac regenerative medicine requires the efficient generation, structural soundness and proper functioning of mature cardiomyocytes, derived from the patient's somatic cells. The most important functional property of cardiomyocytes is the… read more here.
Keywords: free cultures; manipulation free; derived cardiomyocytes; cultures human ... See more keywords
Human ESC-Derived Cardiomyocytes Restore Function in Infarcted Hearts of Non-Human Primates
Sign Up to like & getrecommendations! Published in 2018 at "Nature biotechnology"
DOI: 10.1038/nbt.4162
Abstract: Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some settings cause ventricular arrhythmias. It is unknown whether human cardiomyocytes can restore cardiac… read more here.
Keywords: restore function; derived cardiomyocytes; cardiomyocytes restore; esc derived ... See more keywords