Chicken‐derived CD20 antibodies with potent B‐cell depletion activity
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DOI: 10.1111/bjh.18438
Abstract: We report four novel anti‐human CD20 (hCD20) monoclonal antibodies (mAbs) discovered from a phylogenetically distant species—chickens. The chicken–human chimaeric antibodies exhibit at least 10‐fold enhanced antibody‐dependent cellular cytotoxicity (ADCC) and 4–8‐fold stronger complement‐dependent cytotoxicity (CDC)… read more here.
Keywords: cell; cd20 antibodies; cell depletion; depletion ... See more keywords