Single‐Cell RNA Sequencing Reveals Heterogeneity of Myf5‐Derived Cells and Altered Myogenic Fate in the Absence of SRSF2
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105775
Abstract: Splicing factor SRSF2 acts as a critical regulator for cell survival, however, it remains unknown whether SRSF2 is involved in myoblast proliferation and myogenesis. Here, knockdown of SRSF2 in myoblasts causes high rates of apoptosis… read more here.
Keywords: cell; myf5 derived; absence; fate ... See more keywords
Developmental differences between neonatal and adult human erythropoiesis
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25015
Abstract: Studies of human erythropoiesis have relied, for the most part, on the in vitro differentiation of hematopoietic stem and progenitor cells (HSPC) from different sources. Here, we report that despite the common core erythroid program… read more here.
Keywords: erythroid differentiation; human erythropoiesis; developmental differences; differentiation ... See more keywords
The role of β‐adrenergic receptors and p38MAPK signaling pathways in physiological processes of cardiosphere‐derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26292
Abstract: The effects of β adrenergic receptors (β‐ARs) and p38 mitogen‐activated protein kinases (MAPK) pathways on cardiosphere‐derived cells (CDCs) are largely unknown. This study aimed to investigate the roles of β‐ARs and p38MAPK pathways on the… read more here.
Keywords: p38mapk signaling; signaling pathways; adrenergic receptors; group ... See more keywords
Technologies for Live Imaging of Enteric Neural Crest-Derived Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9412-0_8
Abstract: Time-lapse imaging of gut explants from embryonic mice in which neural crest-derived cells express fluorescent proteins allows the behavior of enteric neural crest cells to be observed and analyzed. Explants of embryonic gut are dissected,… read more here.
Keywords: crest derived; technologies live; crest; enteric neural ... See more keywords
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00913-y
Abstract: Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs’ cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using… read more here.
Keywords: cells cdcs; cardiosphere derived; molecular identity; cell ... See more keywords
A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-018-4134-2
Abstract: PurposeTo create new immunodeficient Royal College of Surgeons (RCS) rats by introducing the defective MerTK gene into athymic nude rats.MethodsFemale homozygous RCS (RCS-p+/RCS-p+) and male nude rats (Hsd:RH-Foxn1mu, mutation in the foxn1 gene; no T… read more here.
Keywords: new immunodeficient; human derived; transplantation; derived cells ... See more keywords
Immunological Issues After Stem Cell-Based β Cell Replacement
Sign Up to like & getrecommendations! Published in 2017 at "Current Diabetes Reports"
DOI: 10.1007/s11892-017-0901-4
Abstract: Purpose of ReviewIslet and pancreas transplantation prove that β cell replacement can cure the glycemic derangements in type 1 diabetes (T1D). Induced pluripotent stem cells (iPSCs) can differentiate into functional insulin-producing cells, able to restore… read more here.
Keywords: cell replacement; stem cell; immunological issues; issues stem ... See more keywords
Jagged1 promotes mineralization in human bone-derived cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.01.013
Abstract: OBJECTIVES The present study aimed to investigate the expression of Notch signaling components during osteogenic differentiation in vitro and bone healing in vivo. In addition, the influence of Notch signaling on osteogenic differentiation of human… read more here.
Keywords: human bone; bone; expression; bone derived ... See more keywords
Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modelling SBMA.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.05.003
Abstract: Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a motor neuron disease caused by the expansion of a polymorphic CAG tandem repeat encoding a polyglutamine (polyQ) tract in the androgen receptor… read more here.
Keywords: motoneuron derived; ionic currents; igf pacap; derived cells ... See more keywords
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.08.009
Abstract: Most tissue-resident macrophage (RTM) populations are seeded by waves of embryonic hematopoiesis and are self-maintained independently of a bone marrow contribution during adulthood. A proportion of RTMs, however, is constantly replaced by blood monocytes, and… read more here.
Keywords: via ms4a3; fate mapping; mapping via; derived cells ... See more keywords
A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.024
Abstract: Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more… read more here.
Keywords: subset monocyte; discrete subset; dendritic cells; derived cells ... See more keywords