Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2017.4097
Abstract: Importance Retinoblastoma (Rb) is one of the first tumors to have a known genetic etiology. However, because biopsy of this tumor is contraindicated, it has not been possible to define the effects of secondary genetic… read more here.
Keywords: copy number; dna; aqueous humor; tumor derived ... See more keywords
α-Cyperone Inhibitory Effects on Tumor-Derived DNA Trigger Microglia by STING Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113246
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cyperus rotundus L. (Cyperaceae) is a widespread herbal in China and widely used in Traditional Chinese Medicine for multiple effects such as anti-arthritic, anti-genotoxic, anti-mutagenic, anti-bacterial effects, and analgesic. α-Cyperone is an active… read more here.
Keywords: inhibitory effects; tumor derived; effects tumor; trigger microglia ... See more keywords
Pathophysiological functions of self-derived DNA
Sign Up to like & getrecommendations! Published in 2022 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2022.2070616
Abstract: Abstract Inflammation plays indispensable roles in building the immune responses such as acquired immunity against harmful pathogens. Furthermore, it is essential for maintaining biological homeostasis in ever-changing conditions. Pattern-recognition receptors (PRRs) reside in cell membranes,… read more here.
Keywords: functions self; pathophysiological functions; derived dna; self derived ... See more keywords
Accurate and precise targeted NGS with BRCA MASTR Plus Dx for BRCA1 and BRCA2 mutation detection in formalin-fixed paraffin-embedded tumor tissue-derived DNA.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e23116
Abstract: e23116Background: Targeted next-generation sequencing (NGS) has tremendous potential in clinical diagnostics as it allows oncogenetic profiling to steer therapy. Inhibitors of poly-(ADP-ribose) polymerase (PARPi) have emerged as a new class of targeted anti-cancer drugs, specifically… read more here.
Keywords: fixed paraffin; mastr plus; formalin fixed; brca1 brca2 ... See more keywords
Expanding the Non-Invasive Diagnosis of Acute Rejection in Kidney Transplants Through Detection of Donor-Derived DNA in Urine: Proof-of-Concept Study
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2021.41.5.469
Abstract: Background Approximately 10%-20% of kidney transplant (KT) recipients suffer from acute rejection (AR); thus, sensitive and accurate monitoring of allograft status is recommended. We evaluated the clinical utility of donor-derived DNA (dd-DNA) detection in the… read more here.
Keywords: dna; dna ucr; acute rejection; donor derived ... See more keywords
Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.970242
Abstract: Advances in Next Generation Sequencing (NGS) technologies have enabled the accurate detection and quantification of circulating tumor-derived (ct)DNA in most gastrointestinal (GI) cancers. The prognostic and predictive utility of ctDNA in patiets with different stages… read more here.
Keywords: circulating tumor; gastrointestinal cancers; ctdna; tumor derived ... See more keywords