T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice
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DOI: 10.1007/s00535-017-1341-2
Abstract: BackgroundEndogenous opioids, including enkephalins, are fundamental regulators of pain. In inflammatory conditions, the local release of opioids by leukocytes at the inflammatory site inhibits nociceptor firing, thereby inducing analgesia. Accordingly, in chronic intestinal Th1/Th17-associated inflammation,… read more here.
Keywords: derived enkephalins; inflammation; colitis; th1 th17 ... See more keywords