Adult cardiomyocytes‐derived EVs for the treatment of cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12461
Abstract: Abstract Cardiac fibrosis is a common pathological feature of cardiovascular diseases that arises from the hyperactivation of fibroblasts and excessive extracellular matrix (ECM) deposition, leading to impaired cardiac function and potentially heart failure or arrhythmia.… read more here.
Keywords: derived evs; treatment cardiac; treatment; fibrosis ... See more keywords
microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09597-x
Abstract: AIM Given the fact that tumor-associated macrophage-derived extracellular vesicles (EVs) are attributable to tumor aggressiveness, this research intends to decode the mechanism of M2 macrophage-derived EVs in the differentiation and activities of pancreatic cancer (PaCa)… read more here.
Keywords: differentiation; derived evs; macrophage derived; stem ... See more keywords
Synergistic Interaction between Polysaccharide-Based Extracellular Matrix and Mineralized Osteoblast-Derived EVs Promotes Bone Regeneration via miRNA-mRNA Regulatory Axis.
Sign Up to like & getrecommendations! Published in 2024 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c00269
Abstract: Extracellular vesicles (EVs) derived from bone progenitor cells are advantageous as cell-free and non-immunogenic cargo delivery vehicles. In this study, EVs are isolated from MC3T3-E1 cells before (GM-EVs) and after mineralization for 7 and 14… read more here.
Keywords: derived evs; extracellular matrix; mrna regulatory; evs ... See more keywords
Regulatory T cell-derived extracellular vesicles modify dendritic cell function
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24531-8
Abstract: Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and limit other immune responses. They achieve this through different mechanisms including the release of extracellular vesicles (EVs) such as… read more here.
Keywords: extracellular vesicles; treg derived; regulatory cell; derived evs ... See more keywords
New Optical Imaging Reporter-labeled Anaplastic Thyroid Cancer-Derived Extracellular Vesicles as a Platform for In Vivo Tumor Targeting in a Mouse Model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31998-y
Abstract: Extracellular vesicles (EVs), originating from multivesicular bodies by invagination of the endosomal membrane, are communication channels between distant cells. They are natural carriers of exogeneous cellular materials and have been exploited as drug delivery carriers… read more here.
Keywords: cell derived; optical imaging; cancer; derived evs ... See more keywords
Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96313-8
Abstract: Vascular endothelial growth factor (VEGF) has been implicated in the pathophysiology of stress-related mental disorders. However, VEGF levels have seldom been compared across mental disorders and never by isoforms. Pathophysiological processes involving leakage of astrocyte-derived… read more here.
Keywords: vegf; stress related; mental disorders; astrocyte derived ... See more keywords
Revealing the complexity of the epicardial secretome
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-24980-y
Abstract: The epicardium, an epithelial layer covering the heart, plays pivotal roles in embryonic heart development and responses to adult cardiac damage. Epicardial-secreted molecular agents are known to be involved in the regulation of these phenomena,… read more here.
Keywords: derived evs; epicardial derived; epicardial secretome; epic ecm ... See more keywords
Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr08108j
Abstract: Extracellular vesicles (EVs) have emerged as cell-free nanotherapeutic agents for the potential treatment of multiple diseases and for tissue engineering and regenerative medicine strategies. Nevertheless, the field has typically relied on EVs derived from stem… read more here.
Keywords: extracellular vesicles; platelet; controlling fate; platelet derived ... See more keywords
Immunosuppressive Effects of Multiple Myeloma‐Derived Extracellular Vesicles Through T Cell Exhaustion
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Science"
DOI: 10.1111/cas.70099
Abstract: Extracellular vehicles (EVs) are reported to be involved in several processes relating to tumor progression, including angiogenesis, osteolysis, and drug resistance in multiple myeloma (MM). However, the role of EVs in the immune‐suppressive milieu of… read more here.
Keywords: derived evs; multiple myeloma; exhaustion; immunosuppressive effects ... See more keywords
Extracellular Vesicles of Salivary Adenoid Cystic Carcinoma Suppress Immune Microenvironment in Lung.
Sign Up to like & getrecommendations! Published in 2025 at "Oral diseases"
DOI: 10.1111/odi.70065
Abstract: OBJECTIVE Salivary adenoid cystic carcinoma (SACC) frequently metastasizes to the lung and affects patient survival. Extracellular vesicles (EVs) have significant effects in the tumor pre-metastatic niche (PMN). In this study, we aimed to investigate immune… read more here.
Keywords: derived evs; lung; adenoid cystic; sacc derived ... See more keywords
Pseudomonas aeruginosa-Derived Extracellular Vesicles Modulate Corneal Inflammation: Role in Microbial Keratitis?
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00036-23
Abstract: Pseudomonas aeruginosa keratitis occurs following trauma, in immunocompromised patients, and in otherwise healthy contact lens wearers. Characterized by a light-blocking infiltrate, P. aeruginosa keratitis is the most serious complication associated with contact lens wear and,… read more here.
Keywords: pseudomonas aeruginosa; keratitis; aeruginosa derived; aeruginosa keratitis ... See more keywords