Abstract We0007: Transcriptional Profiling Identifies Bhlhe40 as a Key Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.we0007
Abstract: A defining feature of atherosclerosis is the uptake of oxidized lipids by cells, leading them to differentiate into foam cells. Foam cells were once believed to originate primarily from macrophages. However, recent research suggests that… read more here.
Keywords: vsmc derived; cell; foam cells; phenotypic modulation ... See more keywords
An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1481505
Abstract: Excess cholesterol accumulation induces the accumulation of foam cells, eventually accelerating atherosclerosis progress. Historically, the mechanisms of macrophage-derived foam cells have attracted attention because of their central role in plaque development, which was challenged by… read more here.
Keywords: vascular smooth; atherosclerosis; foam cells; smooth muscle ... See more keywords
Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01592
Abstract: Cholesterol-laden, foam macrophages constitute the most characteristic component of human atherosclerotic plaques. Persistent uptake of oxLDLs results in accumulation of lipid bodies inside the cells and determines their phenotype and subsequent functions. In this work,… read more here.
Keywords: oxldls; human monocyte; derived foam; foam cells ... See more keywords