tRNA-derived fragments as new players in regulatory processes in yeast.
Sign Up to like & getrecommendations! Published in 2022 at "Yeast"
DOI: 10.1002/yea.3829
Abstract: For a very long time, RNA molecules were treated as transistory molecules, by which the genetic information flows from DNA to proteins; the model proposed in the 1960s accepted that proteins are both, the products… read more here.
Keywords: fragments new; derived fragments; noncoding rnas; trna derived ... See more keywords
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.05.013
Abstract: Arginyltransferase ATE1 mediates posttranslational arginylation and plays key roles in multiple physiological processes. ATE1 utilizes arginyl (Arg)-tRNAArg as the donor of Arg, putting this reaction into a direct competition with the protein synthesis machinery. Here,… read more here.
Keywords: trnaarg derived; trnaarg; arginylation; fragments serve ... See more keywords
Identification of transfer RNA-derived fragments and their potential roles in aortic dissection.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.06.039
Abstract: Emerging evidence suggests that majority of the transfer RNA (tRNA)-derived small RNA, including tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), play a significant role in the molecular mechanisms underlying some human diseases. However, expression of… read more here.
Keywords: roles aortic; trfs tirnas; aortic dissection; transfer rna ... See more keywords
Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab017
Abstract: Decreased fertility is becoming an important social and medical problem and the male factor is involved in at least half of infertility cases. Since conventional semen analysis provides limited prediction of male fertility, in this… read more here.
Keywords: derived fragments; levels seminal; normozoospermic men; trna derived ... See more keywords
Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats.
Sign Up to like & getrecommendations! Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2020-0193
Abstract: Aim: To illustrate the expression profile of transfer RNA-derived fragments and reveal their putative role in the pathogenesis of diabetic cataract (DC) rats. Materials & methods: Small RNA sequencing was conducted in the lens epithelium… read more here.
Keywords: identification trna; trna derived; cataract rats; diabetic cataract ... See more keywords
Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1049251
Abstract: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus that can cause malignant arrhythmia and sudden death and is associated with cardiomyocyte dysfunction induced by hyperglycemia. Emerging evidence has revealed that transfer RNA-derived fragments… read more here.
Keywords: cell; derived fragments; signaling pathway; trfs ... See more keywords
tRNA derived fragments:A novel player in gene regulation and applications in cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1063930
Abstract: The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation, has been demonstrated. In this… read more here.
Keywords: derived fragments; trna derived; fragments novel; regulation ... See more keywords
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10010136
Abstract: Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI… read more here.
Keywords: derived fragments; neuroinflammation; tbi; rna derived ... See more keywords
Characteristics of Transfer RNA-Derived Fragments Expressed during Human Renal Cell Development: The Role of Dicer in tRF Biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073644
Abstract: tRNA-derived fragments participate in the regulation of many processes, such as gene silencing, splicing and translation in many organisms, ranging from bacteria to humans. We were interested to know how tRF abundance changes during the… read more here.
Keywords: derived fragments; dicer; renal cell; human renal ... See more keywords
Expression profile of tRNA-derived fragments and their potential roles in human varicose veins
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10544
Abstract: Varicose veins (VVs) is a common disease presenting with chronic venous insufficiency. tRNA-derived fragments (tRFs) are associated with a variety of pathological conditions. However, the functions of tRFs in VVs have not been elucidated to… read more here.
Keywords: trfs; trna derived; trf; varicose veins ... See more keywords
Identification of tRNA‑derived fragments in colon cancer by comprehensive small RNA sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2019.7178
Abstract: Transfer RNA‑derived fragments (tRFs) are a novel class of small non‑coding RNAs that are abundant in various species and have been implicated in human diseases. However, to the best of our knowledge, the role of… read more here.
Keywords: trfs; key mirnas; colon; colon cancer ... See more keywords