Chimeric antigen receptor‐modified T‐cell therapy for platelet‐derived growth factor receptor α‐positive rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.32764
Abstract: New immunotherapeutic approaches are urgently needed for metastatic rhabdomyosarcoma, which is associated with poor survival and unsatisfactory treatment outcomes. Platelet‐derived growth factor receptor α (PDGFRA) plays an essential role in the onset and development of… read more here.
Keywords: growth factor; rhabdomyosarcoma; receptor; factor receptor ... See more keywords
Correlation between platelet‐derived growth factor‐B gene polymorphism and coronary heart disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24683
Abstract: The aim of the present work was to investigate the correlation of plasma platelet‐derived growth factor (PDGF)‐BB level and single nucleotide polymorphism (SNP, rs1800817 and rs2285094) of PDGF‐B gene with the onset and stability condition… read more here.
Keywords: coronary heart; correlation; growth factor; derived growth ... See more keywords
Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12007
Abstract: Abstract Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF… read more here.
Keywords: derived growth; disease; hepatoma derived; hdgf ... See more keywords
Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and pro-angiogenic property
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2641-7
Abstract: Mesenchymal stem cells (MSCs) are heterogeneous likely consisting of subpopulations with various therapeutic potentials. Here we attempted to acquire a subset of MSCs with enhanced effect in wound healing. We found that human placental MSCs… read more here.
Keywords: derived growth; mscs; stem cells; platelet derived ... See more keywords
Ultrastructural and Molecular Characterization of Platelet-derived growth factor Beta-Positive Leptomeningeal Cells in the Adult Rat Brain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01793-5
Abstract: The leptomeninges, referring to the arachnoid and pia mater and their projections into the perivascular compartments in the central nervous system, actively participate in diverse biological processes including fluid homeostasis, immune cell infiltrations, and neurogenesis,… read more here.
Keywords: pdgfr cells; factor beta; growth factor; pdgfr ... See more keywords
Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads
Sign Up to like & getrecommendations! Published in 2017 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2017.10.003
Abstract: Platelet derived growth factor beta receptor (PDGFR- β) plays an important role in angiogenesis. PDGFR-β expression is correlated with increased vascularity and maturation of blood vessels in cancer. Pharmacophore modeling and quantitative structure-activity relationship (QSAR)… read more here.
Keywords: angiogenesis; factor beta; beta receptor; growth factor ... See more keywords
Plasma Concentrations of Myeloid-Derived Growth Factor in Healthy Individuals and Patients with Acute Myocardial Infarction as Assessed by Multiple Reaction Monitoring-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b03041
Abstract: Myeloid-derived growth factor (MYDGF in humans, Mydgf in mice) is a secreted protein with previously unknown biological functions. In a recent study, Mydgf was shown to mediate cardiac repair after acute myocardial infarction (MI) in… read more here.
Keywords: patients acute; myocardial infarction; growth factor; acute myocardial ... See more keywords
Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01732
Abstract: Platelet-derived growth factor receptors (PDGFRs) are now considered promising targets for the treatment of osteosarcoma. Herein, the design, synthesis, and structure-activity relationships (SAR) of novel pyrimidine-2,4-diamine derivatives that selectively inhibit PDGFRα/β kinases have been studied.… read more here.
Keywords: treatment osteosarcoma; pdgfr; growth factor; derived growth ... See more keywords
Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b13760
Abstract: Using delivery systems to control the in vivo release of growth factors (GFs) for tissue engineering applications is extremely desirable as the clinical use of GFs is limited by their fast in vivo turnover. Hence,… read more here.
Keywords: vivo; growth factor; growth; platelet derived ... See more keywords
Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
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DOI: 10.1038/s41598-019-46510-3
Abstract: Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain.… read more here.
Keywords: growth factor; cohort; expression; pdgfr ... See more keywords
Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15851
Abstract: Although no effective therapy is available to stop or reverse CKD progression targeting its key feature, the loss of peritubular capillaries (PTCs) leading to interstitial fibrosis, myeloid‐derived growth factor (MYDGF) with tissue‐repairing activities enlightens its… read more here.
Keywords: derived growth; myeloid derived; growth factor; mucin fused ... See more keywords